GUT MICROBIOTA IN METABOLIC AND INFLAMMATORY DISEASES
Concetta Scimone

ABSTRACT
Human body is colonized by more than 5000 different bacteria species living in symbiosis with the host. Most of them, however, inhabit intestinal tract and perform vital functions for the host, as metabolism, differentiation of gut epithelium, modulation of immune system. Many factors can influence equilibrium of normal flora and, among these, host genetic features, nutrients, lifestyle. Pathogenesis of several bowel and metabolic disorders is not well elucidated. Application of omics sciences for molecular characterization of gut microbiota is proving the high impact of gastrointestinal bacteria in development of inflammatory bowel diseases, as Crohn disease, and metabolic disorders, like diabetes mellitus and obesity. Here we focused on the main pathological conditions, with particular attention to the role of microbiota.

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