World Alzheimer Report<\/em>. 2021.<\/p>\r\n\r\n\r\n\r\n2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Richard, R. and S. Mousa. (2022). Necroptosis in Alzheimer’s disease: Potential therapeutic target. Biomed Pharmacother, 152, 113203.<\/p>\r\n\r\n\r\n\r\n
3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ossenkoppele, R., Y.A. Pijnenburg, D.C. Perry, B.I. Cohn-Sheehy, N.M. Scheltens, J.W. Vogel, J.H. Kramer, A.E. van der Vlies, R. La Joie, H.J. Rosen, W.M. van der Flier, L.T. Grinberg, A.J. Rozemuller, E.J. Huang, B.N. van Berckel, B.L. Miller, F. Barkhof, W.J. Jagust, P. Scheltens, W.W. Seeley, and G.D. Rabinovici. (2015). The behavioural\/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features. Brain, 138(Pt 9), 2732-49.<\/p>\r\n\r\n\r\n\r\n
4.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Timpson, N.J., C.M.T. Greenwood, N. Soranzo, D.J. Lawson, and J.B. Richards. (2018). Genetic architecture: the shape of the genetic contribution to human traits and disease. Nat Rev Genet, 19(2), 110-124.<\/p>\r\n\r\n\r\n\r\n
5.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Khani, M., E. Gibbons, J. Bras, and R. Guerreiro. (2022). Challenge accepted: uncovering the role of rare genetic variants in Alzheimer’s disease. Mol Neurodegener, 17(1), 3.<\/p>\r\n\r\n\r\n\r\n
6.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Coon, K.D., A.J. Myers, D.W. Craig, J.A. Webster, J.V. Pearson, D.H. Lince, V.L. Zismann, T.G. Beach, D. Leung, L. Bryden, R.F. Halperin, L. Marlowe, M. Kaleem, D.G. Walker, R. Ravid, C.B. Heward, J. Rogers, A. Papassotiropoulos, E.M. Reiman, J. Hardy, and D.A. Stephan. (2007). A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer’s disease. J Clin Psychiatry, 68(4), 613-8.<\/p>\r\n\r\n\r\n\r\n
7.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bellenguez, C., F. Kucukali, I.E. Jansen, L. Kleineidam, S. Moreno-Grau, N. Amin, A.C. Naj, R. Campos-Martin, B. Grenier-Boley, V. Andrade, P.A. Holmans, A. Boland, V. Damotte, S.J. van der Lee, M.R. Costa, T. Kuulasmaa, Q. Yang, I. de Rojas, J.C. Bis, A. Yaqub, I. Prokic, J. Chapuis, S. Ahmad, V. Giedraitis, D. Aarsland, P. Garcia-Gonzalez, C. Abdelnour, E. Alarcon-Martin, D. Alcolea, M. Alegret, I. Alvarez, V. Alvarez, N.J. Armstrong, A. Tsolaki, C. Antunez, I. Appollonio, M. Arcaro, S. Archetti, A.A. Pastor, B. Arosio, L. Athanasiu, H. Bailly, N. Banaj, M. Baquero, S. Barral, A. Beiser, A.B. Pastor, J.E. Below, P. Benchek, L. Benussi, C. Berr, C. Besse, V. Bessi, G. Binetti, A. Bizarro, R. Blesa, M. Boada, E. Boerwinkle, B. Borroni, S. Boschi, P. Bossu, G. Brathen, J. Bressler, C. Bresner, H. Brodaty, K.J. Brookes, L.I. Brusco, D. Buiza-Rueda, K. Burger, V. Burholt, W.S. Bush, M. Calero, L.B. Cantwell, G. Chene, J. Chung, M.L. Cuccaro, A. Carracedo, R. Cecchetti, L. Cervera-Carles, C. Charbonnier, H.H. Chen, C. Chillotti, S. Ciccone, J. Claassen, C. Clark, E. Conti, A. Corma-Gomez, E. Costantini, C. Custodero, D. Daian, M.C. Dalmasso, A. Daniele, E. Dardiotis, J.F. Dartigues, P.P. de Deyn, K. de Paiva Lopes, L.D. de Witte, S. Debette, J. Deckert, T. Del Ser, N. Denning, A. DeStefano, M. Dichgans, J. Diehl-Schmid, M. Diez-Fairen, P.D. Rossi, S. Djurovic, E. Duron, E. Duzel, C. Dufouil, G. Eiriksdottir, S. Engelborghs, V. Escott-Price, A. Espinosa, M. Ewers, K.M. Faber, T. Fabrizio, S.F. Nielsen, D.W. Fardo, L. Farotti, C. Fenoglio, M. Fernandez-Fuertes, R. Ferrari, C.B. Ferreira, E. Ferri, B. Fin, P. Fischer, T. Fladby, K. Fliessbach, B. Fongang, M. Fornage, J. Fortea, T.M. Foroud, S. Fostinelli, N.C. Fox, E. Franco-Macias, M.J. Bullido, A. Frank-Garcia, L. Froelich, B. Fulton-Howard, D. Galimberti, J.M. Garcia-Alberca, P. Garcia-Gonzalez, S. Garcia-Madrona, G. Garcia-Ribas, R. Ghidoni, I. Giegling, G. Giorgio, A.M. Goate, O. Goldhardt, D. Gomez-Fonseca, A. Gonzalez-Perez, C. Graff, G. Grande, E. Green, T. Grimmer, E. Grunblatt, M. Grunin, V. Gudnason, T. Guetta-Baranes, A. Haapasalo, G. Hadjigeorgiou, J.L. Haines, K.L. Hamilton-Nelson, H. Hampel, O. Hanon, J. Hardy, A.M. Hartmann, L. Hausner, J. Harwood, S. Heilmann-Heimbach, S. Helisalmi, M.T. Heneka, I. Hernandez, M.J. Herrmann, P. Hoffmann, C. Holmes, H. Holstege, R.H. Vilas, M. Hulsman, J. Humphrey, G.J. Biessels, X. Jian, C. Johansson, G.R. Jun, Y. Kastumata, J. Kauwe, P.G. Kehoe, L. Kilander, A.K. Stahlbom, M. Kivipelto, A. Koivisto, J. Kornhuber, M.H. Kosmidis, W.A. Kukull, P.P. Kuksa, B.W. Kunkle, A.B. Kuzma, C. Lage, E.J. Laukka, L. Launer, A. Lauria, C.Y. Lee, J. Lehtisalo, O. Lerch, A. Lleo, W. Longstreth, Jr., O. Lopez, A.L. de Munain, S. Love, M. Lowemark, L. Luckcuck, K.L. Lunetta, Y. Ma, J. Macias, C.A. MacLeod, W. Maier, F. Mangialasche, M. Spallazzi, M. Marquie, R. Marshall, E.R. Martin, A.M. Montes, C.M. Rodriguez, C. Masullo, R. Mayeux, S. Mead, P. Mecocci, M. Medina, A. Meggy, S. Mehrabian, S. Mendoza, M. Menendez-Gonzalez, P. Mir, S. Moebus, M. Mol, L. Molina-Porcel, L. Montrreal, L. Morelli, F. Moreno, K. Morgan, T. Mosley, M.M. Nothen, C. Muchnik, S. Mukherjee, B. Nacmias, T. Ngandu, G. Nicolas, B.G. Nordestgaard, R. Olaso, A. Orellana, M. Orsini, G. Ortega, A. Padovani, C. Paolo, G. Papenberg, L. Parnetti, F. Pasquier, P. Pastor, G. Peloso, A. Perez-Cordon, J. Perez-Tur, P. Pericard, O. Peters, Y.A.L. Pijnenburg, J.A. Pineda, G. Pinol-Ripoll, C. Pisanu, T. Polak, J. Popp, D. Posthuma, J. Priller, R. Puerta, O. Quenez, I. Quintela, J.Q. Thomassen, A. Rabano, I. Rainero, F. Rajabli, I. Ramakers, L.M. Real, M.J.T. Reinders, C. Reitz, D. Reyes-Dumeyer, P. Ridge, S. Riedel-Heller, P. Riederer, N. Roberto, E. Rodriguez-Rodriguez, A. Rongve, I.R. Allende, M. Rosende-Roca, J.L. Royo, E. Rubino, D. Rujescu, M.E. Saez, P. Sakka, I. Saltvedt, A. Sanabria, M.B. Sanchez-Arjona, F. Sanchez-Garcia, P.S. Juan, R. Sanchez-Valle, S.B. Sando, C. Sarnowski, C.L. Satizabal, M. Scamosci, N. Scarmeas, E. Scarpini, P. Scheltens, N. Scherbaum, M. Scherer, M. Schmid, A. Schneider, J.M. Schott, G. Selbaek, D. Seripa, M. Serrano, J. Sha, A.A. Shadrin, O. Skrobot, S. Slifer, G.J.L. Snijders, H. Soininen, V. Solfrizzi, A. Solomon, Y. Song, S. Sorbi, O. Sotolongo-Grau, G. Spalletta, A. Spottke, A. Squassina, E. Stordal, J.P. Tartan, L. Tarraga, N. Tesi, A. Thalamuthu, T. Thomas, G. Tosto, L. Traykov, L. Tremolizzo, A. Tybjaerg-Hansen, A. Uitterlinden, A. Ullgren, I. Ulstein, S. Valero, O. Valladares, C.V. Broeckhoven, J. Vance, B.N. Vardarajan, A. van der Lugt, J.V. Dongen, J. van Rooij, J. van Swieten, R. Vandenberghe, F. Verhey, J.S. Vidal, J. Vogelgsang, M. Vyhnalek, M. Wagner, D. Wallon, L.S. Wang, R. Wang, L. Weinhold, J. Wiltfang, G. Windle, B. Woods, M. Yannakoulia, H. Zare, Y. Zhao, X. Zhang, C. Zhu, M. Zulaica, Eadb, Gr@Ace, Degesco, Eadi, Gerad, Demgene, FinnGen, Adgc, Charge, L.A. Farrer, B.M. Psaty, M. Ghanbari, T. Raj, P. Sachdev, K. Mather, F. Jessen, M.A. Ikram, A. de Mendonca, J. Hort, M. Tsolaki, M.A. Pericak-Vance, P. Amouyel, J. Williams, R. Frikke-Schmidt, J. Clarimon, J.F. Deleuze, G. Rossi, S. Seshadri, O.A. Andreassen, M. Ingelsson, M. Hiltunen, K. Sleegers, G.D. Schellenberg, C.M. van Duijn, R. Sims, W.M. van der Flier, A. Ruiz, A. Ramirez and J.C. Lambert. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet, 54(4), 412-436.<\/p>\r\n\r\n\r\n\r\n
8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Graff-Radford, J., K.X.X. Yong, L.G. Apostolova, F.H. Bouwman, M. Carrillo, B.C. Dickerson, G.D. Rabinovici, J.M. Schott, D.T. Jones, and M.E. Murray. (2021). New insights into atypical Alzheimer’s disease in the era of biomarkers. Lancet Neurol, 20(3), 222-234.<\/p>\r\n\r\n\r\n\r\n
9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Schott, J.M., S.J. Crutch, M.M. Carrasquillo, J. Uphill, T.J. Shakespeare, N.S. Ryan, K.X. Yong, M. Lehmann, N. Ertekin-Taner, N.R. Graff-Radford, B.F. Boeve, M.E. Murray, Q.U. Khan, R.C. Petersen, D.W. Dickson, D.S. Knopman, G.D. Rabinovici, B.L. Miller, A.S. Gonzalez, E. Gil-Neciga, J.S. Snowden, J. Harris, S.M. Pickering-Brown, E. Louwersheimer, W.M. van der Flier, P. Scheltens, Y.A. Pijnenburg, D. Galasko, M. Sarazin, B. Dubois, E. Magnin, D. Galimberti, E. Scarpini, S.F. Cappa, J.R. Hodges, G.M. Halliday, L. Bartley, M.C. Carrillo, J.T. Bras, J. Hardy, M.N. Rossor, J. Collinge, N.C. Fox, and S. Mead. (2016). Genetic risk factors for the posterior cortical atrophy variant of Alzheimer’s disease. Alzheimers Dement, 12(8), 862-71.<\/p>\r\n\r\n\r\n\r\n
10.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bras, J., R. Djaldetti, A.M. Alves, S. Mead, L. Darwent, A. Lleo, J.L. Molinuevo, R. Blesa, A. Singleton, J. Hardy, J. Clarimon, and R. Guerreiro. (2016). Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer’s disease identifies a homozygous CTSF mutation. Neurobiol Aging, 46, 236 e1-6.<\/p>\r\n\r\n\r\n\r\n
11.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Conway, O.J., M.M. Carrasquillo, X. Wang, J.M. Bredenberg, J.S. Reddy, S.L. Strickland, C.S. Younkin, J.D. Burgess, M. Allen, S.J. Lincoln, T. Nguyen, K.G. Malphrus, A.I. Soto, R.L. Walton, B.F. Boeve, R.C. Petersen, J.A. Lucas, T.J. Ferman, W.P. Cheshire, J.A. van Gerpen, R.J. Uitti, Z.K. Wszolek, O.A. Ross, D.W. Dickson, N.R. Graff-Radford, and N. Ertekin-Taner. (2018). ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans. Mol Neurodegener, 13(1), 53.<\/p>\r\n\r\n\r\n\r\n
12.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Yamazaki, H., H. Bujo, J. Kusunoki, K. Seimiya, T. Kanaki, N. Morisaki, W.J. Schneider, and Y. Saito. (1996). Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member. J Biol Chem, 271(40), 24761-8.<\/p>\r\n\r\n\r\n\r\n
13.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jacobsen, L., P. Madsen, C. Jacobsen, M.S. Nielsen, J. Gliemann, and C.M. Petersen. (2001). Activation and functional characterization of the mosaic receptor SorLA\/LR11. J Biol Chem, 276(25), 22788-96.<\/p>\r\n\r\n\r\n\r\n
14.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jacobsen, L., P. Madsen, S.K. Moestrup, A.H. Lund, N. Tommerup, A. Nykjaer, L. Sottrup-Jensen, J. Gliemann, and C.M. Petersen. (1996). Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. J Biol Chem, 271(49), 31379-83.<\/p>\r\n\r\n\r\n\r\n
15.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Willnow, T.E., C.M. Petersen, and A. Nykjaer. (2008). VPS10P-domain receptors – regulators of neuronal viability and function. Nat Rev Neurosci, 9(12), 899-909.<\/p>\r\n\r\n\r\n\r\n
16.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dodson, S.E., M. Gearing, C.F. Lippa, T.J. Montine, A.I. Levey, and J.J. Lah. (2006). LR11\/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease. J Neuropathol Exp Neurol, 65(9), 866-72.<\/p>\r\n\r\n\r\n\r\n
17.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Scherzer, C.R., K. Offe, M. Gearing, H.D. Rees, G. Fang, C.J. Heilman, C. Schaller, H. Bujo, A.I. Levey, and J.J. Lah. (2004). Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol, 61(8), 1200-5.<\/p>\r\n\r\n\r\n\r\n
18.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Andersen, O.M., I.M. Rudolph, and T.E. Willnow. (2016). Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease. Acta Neuropathol, 132(5), 653-665.<\/p>\r\n\r\n\r\n\r\n
19.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fjorback, A.W., M. Seaman, C. Gustafsen, A. Mehmedbasic, S. Gokool, C. Wu, D. Militz, V. Schmidt, P. Madsen, J.R. Nyengaard, T.E. Willnow, E.I. Christensen, W.B. Mobley, A. Nykjaer, and O.M. Andersen. (2012). Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci, 32(4), 1467-80.<\/p>\r\n\r\n\r\n\r\n
20.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Arighi, C.N., L.M. Hartnell, R.C. Aguilar, C.R. Haft, and J.S. Bonifacino. (2004). Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol, 165(1), 123-33.<\/p>\r\n\r\n\r\n\r\n
21.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Seaman, M.N. (2004). Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol, 165(1), 111-22.<\/p>\r\n\r\n\r\n\r\n
22.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tabuchi, M., I. Yanatori, Y. Kawai, and F. Kishi. (2010). Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1. J Cell Sci, 123(Pt 5), 756-66.<\/p>\r\n\r\n\r\n\r\n
23.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Eaton, S. (2008). Retromer retrieves wntless. Dev Cell, 14(1), 4-6.<\/p>\r\n\r\n\r\n\r\n
24.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Pocha, S.M., T. Wassmer, C. Niehage, B. Hoflack, and E. Knust. (2011). Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs. Curr Biol, 21(13), 1111-7.<\/p>\r\n\r\n\r\n\r\n
25.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hanseeuw, B.J., F. Lopera, R.A. Sperling, D.J. Norton, E. Guzman-Velez, A. Baena, E. Pardilla-Delgado, A.P. Schultz, J. Gatchel, D. Jin, K. Chen, E.M. Reiman, K.A. Johnson, and Y.T. Quiroz. (2019). Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease. Alzheimers Res Ther, 11(1), 17.<\/p>\r\n\r\n\r\n\r\n
26.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ghisays, V., F. Lopera, D.D. Goradia, H.D. Protas, M.H. Malek-Ahmadi, Y. Chen, V. Devadas, J. Luo, W. Lee, A. Baena, Y. Bocanegra, E. Guzman-Velez, E. Pardilla-Delgado, C. Vila-Castelar, J.T. Fox-Fuller, N. Hu, D. Clayton, R.G. Thomas, S. Alvarez, A. Espinosa, N. Acosta-Baena, M.M. Giraldo, S. Rios-Romenets, J.B. Langbaum, K. Chen, Y. Su, P.N. Tariot, Y.T. Quiroz, E.M. Reiman, and A.A.C.T. Group. (2021). PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer’s disease-causing Presenilin-1 E280A mutation carriers. Neuroimage Clin, 31, 102749.<\/p>\r\n\r\n\r\n\r\n
27.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Chen, C.D., N. Joseph-Mathurin, N. Sinha, A. Zhou, Y. Li, K. Friedrichsen, A. McCullough, E.E. Franklin, R. Hornbeck, B. Gordon, V. Sharma, C. Cruchaga, A. Goate, C. Karch, E. McDade, C. Xiong, R.J. Bateman, B. Ghetti, J.M. Ringman, J. Chhatwal, C.L. Masters, C. McLean, T. Lashley, Y. Su, R. Koeppe, C. Jack, W.E. Klunk, J.C. Morris, R.J. Perrin, N.J. Cairns, and T.L.S. Benzinger. (2021). Comparing amyloid-beta plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathol, 142(4), 689-706.<\/p>\r\n\r\n\r\n\r\n
28.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 McDade, E., G. Wang, B.A. Gordon, J. Hassenstab, T.L.S. Benzinger, V. Buckles, A.M. Fagan, D.M. Holtzman, N.J. Cairns, A.M. Goate, D.S. Marcus, J.C. Morris, K. Paumier, C. Xiong, R. Allegri, S.B. Berman, W. Klunk, J. Noble, J. Ringman, B. Ghetti, M. Farlow, R.A. Sperling, J. Chhatwal, S. Salloway, N.R. Graff-Radford, P.R. Schofield, C. Masters, M.N. Rossor, N.C. Fox, J. Levin, M. Jucker, R.J. Bateman, and N. Dominantly Inherited Alzheimer. (2018). Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology, 91(14), e1295-e1306.<\/p>\r\n\r\n\r\n\r\n
29.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hartl, D., G. Nebrich, O. Klein, H. Stephanowitz, E. Krause, and M. Rohe. (2016). SORLA regulates calpain-dependent degradation of synapsin. Alzheimers Dement, 12(9), 952-963.<\/p>\r\n\r\n\r\n\r\n
30.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Huang, T.Y., Y. Zhao, L.L. Jiang, X. Li, Y. Liu, Y. Sun, J.C. Pina-Crespo, B. Zhu, E. Masliah, T.E. Willnow, E.B. Pasquale, and H. Xu. (2017). SORLA attenuates EphA4 signaling and amyloid beta-induced neurodegeneration. J Exp Med, 214(12), 3669-3685.<\/p>\r\n\r\n\r\n\r\n
31.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fu, W.Y., Y. Chen, M. Sahin, X.S. Zhao, L. Shi, J.B. Bikoff, K.O. Lai, W.H. Yung, A.K. Fu, M.E. Greenberg, and N.Y. Ip. (2007). Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci, 10(1), 67-76.<\/p>\r\n\r\n\r\n\r\n
32.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Vargas, L.M., W. Cerpa, F.J. Munoz, S. Zanlungo, and A.R. Alvarez. (2018). Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4\/c-Abl signaling in Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis, 1864(4 Pt A), 1148-1159.<\/p>\r\n\r\n\r\n\r\n
33.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lee, H., A.J. Aylward, R.V. Pearse, Y.C. Hsieh, Z.M. Augur, C.R. Benoit, V. Chou, A. Knupp, C. Pan, S. Goberdhan, D.M. Duong, N.T. Seyfried, D.A. Bennett, H.U. Klein, P.L. De Jager, V. Menon, J.E. Young, and T.L. Young-Pearse. (2023). Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer’s disease risk gene SORL1. bioRxiv.<\/p>\r\n\r\n\r\n\r\n
34.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Mishra, S., A. Knupp, M.P. Szabo, C.A. Williams, C. Kinoshita, D.W. Hailey, Y. Wang, O.M. Andersen, and J.E. Young. (2022). The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. Cell Mol Life Sci, 79(3), 162.<\/p>\r\n\r\n\r\n\r\n
35.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sims, R., S.J. van der Lee, A.C. Naj, C. Bellenguez, N. Badarinarayan, J. Jakobsdottir, B.W. Kunkle, A. Boland, R. Raybould, J.C. Bis, E.R. Martin, B. Grenier-Boley, S. Heilmann-Heimbach, V. Chouraki, A.B. Kuzma, K. Sleegers, M. Vronskaya, A. Ruiz, R.R. Graham, R. Olaso, P. Hoffmann, M.L. Grove, B.N. Vardarajan, M. Hiltunen, M.M. Nothen, C.C. White, K.L. Hamilton-Nelson, J. Epelbaum, W. Maier, S.H. Choi, G.W. Beecham, C. Dulary, S. Herms, A.V. Smith, C.C. Funk, C. Derbois, A.J. Forstner, S. Ahmad, H. Li, D. Bacq, D. Harold, C.L. Satizabal, O. Valladares, A. Squassina, R. Thomas, J.A. Brody, L. Qu, P. Sanchez-Juan, T. Morgan, F.J. Wolters, Y. Zhao, F.S. Garcia, N. Denning, M. Fornage, J. Malamon, M.C.D. Naranjo, E. Majounie, T.H. Mosley, B. Dombroski, D. Wallon, M.K. Lupton, J. Dupuis, P. Whitehead, L. Fratiglioni, C. Medway, X. Jian, S. Mukherjee, L. Keller, K. Brown, H. Lin, L.B. Cantwell, F. Panza, B. McGuinness, S. Moreno-Grau, J.D. Burgess, V. Solfrizzi, P. Proitsi, H.H. Adams, M. Allen, D. Seripa, P. Pastor, L.A. Cupples, N.D. Price, D. Hannequin, A. Frank-Garcia, D. Levy, P. Chakrabarty, P. Caffarra, I. Giegling, A.S. Beiser, V. Giedraitis, H. Hampel, M.E. Garcia, X. Wang, L. Lannfelt, P. Mecocci, G. Eiriksdottir, P.K. Crane, F. Pasquier, V. Boccardi, I. Henandez, R.C. Barber, M. Scherer, L. Tarraga, P.M. Adams, M. Leber, Y. Chen, M.S. Albert, S. Riedel-Heller, V. Emilsson, D. Beekly, A. Braae, R. Schmidt, D. Blacker, C. Masullo, H. Schmidt, R.S. Doody, G. Spalletta, W.T. Longstreth, Jr., T.J. Fairchild, P. Bossu, O.L. Lopez, M.P. Frosch, E. Sacchinelli, B. Ghetti, Q. Yang, R.M. Huebinger, F. Jessen, S. Li, M.I. Kamboh, J. Morris, O. Sotolongo-Grau, M.J. Katz, C. Corcoran, M. Dunstan, A. Braddel, C. Thomas, A. Meggy, R. Marshall, A. Gerrish, J. Chapman, M. Aguilar, S. Taylor, M. Hill, M.D. Fairen, A. Hodges, B. Vellas, H. Soininen, I. Kloszewska, M. Daniilidou, J. Uphill, Y. Patel, J.T. Hughes, J. Lord, J. Turton, A.M. Hartmann, R. Cecchetti, C. Fenoglio, M. Serpente, M. Arcaro, C. Caltagirone, M.D. Orfei, A. Ciaramella, S. Pichler, M. Mayhaus, W. Gu, A. Lleo, J. Fortea, R. Blesa, I.S. Barber, K. Brookes, C. Cupidi, R.G. Maletta, D. Carrell, S. Sorbi, S. Moebus, M. Urbano, A. Pilotto, J. Kornhuber, P. Bosco, S. Todd, D. Craig, J. Johnston, M. Gill, B. Lawlor, A. Lynch, N.C. Fox, J. Hardy, A. Consortium, R.L. Albin, L.G. Apostolova, S.E. Arnold, S. Asthana, C.S. Atwood, C.T. Baldwin, L.L. Barnes, S. Barral, T.G. Beach, J.T. Becker, E.H. Bigio, T.D. Bird, B.F. Boeve, J.D. Bowen, A. Boxer, J.R. Burke, J.M. Burns, J.D. Buxbaum, N.J. Cairns, C. Cao, C.S. Carlson, C.M. Carlsson, R.M. Carney, M.M. Carrasquillo, S.L. Carroll, C.C. Diaz, H.C. Chui, D.G. Clark, D.H. Cribbs, E.A. Crocco, C. DeCarli, M. Dick, R. Duara, D.A. Evans, K.M. Faber, K.B. Fallon, D.W. Fardo, M.R. Farlow, S. Ferris, T.M. Foroud, D.R. Galasko, M. Gearing, D.H. Geschwind, J.R. Gilbert, N.R. Graff-Radford, R.C. Green, J.H. Growdon, R.L. Hamilton, L.E. Harrell, L.S. Honig, M.J. Huentelman, C.M. Hulette, B.T. Hyman, G.P. Jarvik, E. Abner, L.W. Jin, G. Jun, A. Karydas, J.A. Kaye, R. Kim, N.W. Kowall, J.H. Kramer, F.M. LaFerla, J.J. Lah, J.B. Leverenz, A.I. Levey, G. Li, A.P. Lieberman, K.L. Lunetta, C.G. Lyketsos, D.C. Marson, F. Martiniuk, D.C. Mash, E. Masliah, W.C. McCormick, S.M. McCurry, A.N. McDavid, A.C. McKee, M. Mesulam, B.L. Miller, C.A. Miller, J.W. Miller, J.C. Morris, J.R. Murrell, A.J. Myers, S. O’Bryant, J.M. Olichney, V.S. Pankratz, J.E. Parisi, H.L. Paulson, W. Perry, E. Peskind, A. Pierce, W.W. Poon, H. Potter, J.F. Quinn, A. Raj, M. Raskind, B. Reisberg, C. Reitz, J.M. Ringman, E.D. Roberson, E. Rogaeva, H.J. Rosen, R.N. Rosenberg, M.A. Sager, A.J. Saykin, J.A. Schneider, L.S. Schneider, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, R.E. Tanzi, T.A. Thornton-Wells, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh-Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C.E. Yu, L. Yu, F. Garzia, F. Golamaully, G. Septier, S. Engelborghs, R. Vandenberghe, P.P. De Deyn, C.M. Fernadez, Y.A. Benito, H. Thonberg, C. Forsell, L. Lilius, A. Kinhult-Stahlbom, L. Kilander, R. Brundin, L. Concari, S. Helisalmi, A.M. Koivisto, A. Haapasalo, V. Dermecourt, N. Fievet, O. Hanon, C. Dufouil, A. Brice, K. Ritchie, B. Dubois, J.J. Himali, C.D. Keene, J. Tschanz, A.L. Fitzpatrick, W.A. Kukull, M. Norton, T. Aspelund, E.B. Larson, R. Munger, J.I. Rotter, R.B. Lipton, M.J. Bullido, A. Hofman, T.J. Montine, E. Coto, E. Boerwinkle, R.C. Petersen, V. Alvarez, F. Rivadeneira, E.M. Reiman, M. Gallo, C.J. O’Donnell, J.S. Reisch, A.C. Bruni, D.R. Royall, M. Dichgans, M. Sano, D. Galimberti, P. St George-Hyslop, E. Scarpini, D.W. Tsuang, M. Mancuso, U. Bonuccelli, A.R. Winslow, A. Daniele, C.K. Wu, C.A.E. Gerad\/Perades, O. Peters, B. Nacmias, M. Riemenschneider, R. Heun, C. Brayne, D.C. Rubinsztein, J. Bras, R. Guerreiro, A. Al-Chalabi, C.E. Shaw, J. Collinge, D. Mann, M. Tsolaki, J. Clarimon, R. Sussams, S. Lovestone, M.C. O’Donovan, M.J. Owen, T.W. Behrens, S. Mead, A.M. Goate, A.G. Uitterlinden, C. Holmes, C. Cruchaga, M. Ingelsson, D.A. Bennett, J. Powell, T.E. Golde, C. Graff, P.L. De Jager, K. Morgan, N. Ertekin-Taner, O. Combarros, B.M. Psaty, P. Passmore, S.G. Younkin, C. Berr, V. Gudnason, D. Rujescu, D.W. Dickson, J.F. Dartigues, A.L. DeStefano, S. Ortega-Cubero, H. Hakonarson, D. Campion, M. Boada, J.K. Kauwe, L.A. Farrer, C. Van Broeckhoven, M.A. Ikram, L. Jones, J.L. Haines, C. Tzourio, L.J. Launer, V. Escott-Price, R. Mayeux, J.F. Deleuze, N. Amin, P.A. Holmans, M.A. Pericak-Vance, P. Amouyel, C.M. van Duijn, A. Ramirez, L.S. Wang, J.C. Lambert, S. Seshadri, J. Williams and G.D. Schellenberg. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. Nat Genet, 49(9), 1373-1384.<\/p>\r\n\r\n\r\n\r\n
36.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyazaki, K., S. Matsuda, Y. Ichigotani, Y. Takenouchi, K. Hayashi, Y. Fukuda, Y. Nimura, and M. Hamaguchi. (2000). Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein. Biochim Biophys Acta, 1493(1-2), 237-41.<\/p>\r\n\r\n\r\n\r\n
37.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Zipfel, P.A., S.C. Bunnell, D.S. Witherow, J.J. Gu, E.M. Chislock, C. Ring, and A.M. Pendergast. (2006). Role for the Abi\/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. Curr Biol, 16(1), 35-46.<\/p>\r\n\r\n\r\n\r\n
38.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ichigotani, Y., S. Yokozaki, Y. Fukuda, M. Hamaguchi, and S. Matsuda. (2002). Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells. Cancer Res, 62(8), 2215-9.<\/p>\r\n\r\n\r\n\r\n
39.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Satoh, J.I., Y. Kino, M. Yanaizu, Y. Tosaki, K. Sakai, T. Ishida, and Y. Saito. (2017). Microglia express ABI3 in the brains of Alzheimer’s disease and Nasu-Hakola disease. Intractable Rare Dis Res, 6(4), 262-268.<\/p>\r\n\r\n\r\n\r\n
40.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bae, J., B.H. Sung, I.H. Cho, S.M. Kim, and W.K. Song. (2012). NESH regulates dendritic spine morphology and synapse formation. PLoS One, 7(4), e34677.<\/p>\r\n\r\n\r\n\r\n
41.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ibanez, K.R., K.N. McFarland, J. Phillips, M. Allen, C.B. Lessard, L. Zobel, E.G. De La Cruz, S. Shah, Q. Vo, X. Wang, Z. Quicksall, D. Ryu, C. Funk, N. Ertekin-Taner, S. Prokop, T.E. Golde, and P. Chakrabarty. (2022). Deletion of Abi3\/Gngt2 influences age-progressive amyloid beta and tau pathologies in distinctive ways. Alzheimers Res Ther, 14(1), 104.<\/p>\r\n\r\n\r\n\r\n
42.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jagust, W.J., S.M. Landau, and I. Alzheimer’s Disease Neuroimaging. (2021). Temporal Dynamics of beta-Amyloid Accumulation in Aging and Alzheimer Disease. Neurology, 96(9), e1347-e1357.<\/p>\r\n\r\n\r\n\r\n
43.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kaminski, W.E., E. Orso, W. Diederich, J. Klucken, W. Drobnik, and G. Schmitz. (2000). Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem Biophys Res Commun, 273(2), 532-8.<\/p>\r\n\r\n\r\n\r\n
44.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Iwamoto, N., S. Abe-Dohmae, R. Sato, and S. Yokoyama. (2006). ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res, 47(9), 1915-27.<\/p>\r\n\r\n\r\n\r\n
45.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tanaka, N., S. Abe-Dohmae, N. Iwamoto, M.L. Fitzgerald, and S. Yokoyama. (2010). Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J Lipid Res, 51(9), 2591-9.<\/p>\r\n\r\n\r\n\r\n
46.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Satoh, K., S. Abe-Dohmae, S. Yokoyama, P. St George-Hyslop, and P.E. Fraser. (2015). ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem, 290(40), 24152-65.<\/p>\r\n\r\n\r\n\r\n
47.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fu, Y., J.H. Hsiao, G. Paxinos, G.M. Halliday, and W.S. Kim. (2016). ABCA7 Mediates Phagocytic Clearance of Amyloid-beta in the Brain. J Alzheimers Dis, 54(2), 569-84.<\/p>\r\n\r\n\r\n\r\n
48.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kim, W.S., H. Li, K. Ruberu, S. Chan, D.A. Elliott, J.K. Low, D. Cheng, T. Karl, and B. Garner. (2013). Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer’s disease. J Neurosci, 33(10), 4387-94.<\/p>\r\n\r\n\r\n\r\n
49.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lamartiniere, Y., M.C. Boucau, L. Dehouck, M. Krohn, J. Pahnke, P. Candela, F. Gosselet, and L. Fenart. (2018). ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-beta Peptide Efflux in an in vitro Model of the Blood-Brain Barrier. J Alzheimers Dis, 64(4), 1195-1211.<\/p>\r\n\r\n\r\n\r\n
50.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Logge, W., D. Cheng, R. Chesworth, S. Bhatia, B. Garner, W.S. Kim, and T. Karl. (2012). Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases. PLoS One, 7(9), e45959.<\/p>\r\n\r\n\r\n\r\n
51.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Dehghan, A., R.C. Pinto, I. Karaman, J. Huang, B.R. Durainayagam, M. Ghanbari, A. Nazeer, Q. Zhong, S. Liggi, L. Whiley, R. Mustafa, M. Kivipelto, A. Solomon, T. Ngandu, T. Kanekiyo, T. Aikawa, C.I. Radulescu, S.J. Barnes, G. Graca, E. Chekmeneva, S. Camuzeaux, M.R. Lewis, M.R. Kaluarachchi, M.A. Ikram, E. Holmes, I. Tzoulaki, P.M. Matthews, J.L. Griffin, and P. Elliott. (2022). Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease. Proc Natl Acad Sci U S A, 119(43), e2206083119.<\/p>\r\n\r\n\r\n\r\n
52.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Foster, E.M., A. Dangla-Valls, S. Lovestone, E.M. Ribe, and N.J. Buckley. (2019). Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies. Front Neurosci, 13, 164.<\/p>\r\n\r\n\r\n\r\n
53.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jones, S.E. and C. Jomary. (2002). Clusterin. Int J Biochem Cell Biol, 34(5), 427-31.<\/p>\r\n\r\n\r\n\r\n
54.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bertram, L., M.B. McQueen, K. Mullin, D. Blacker, and R.E. Tanzi. (2007). Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet, 39(1), 17-23.<\/p>\r\n\r\n\r\n\r\n
55.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Killick, R., E.M. Ribe, R. Al-Shawi, B. Malik, C. Hooper, C. Fernandes, R. Dobson, P.M. Nolan, A. Lourdusamy, S. Furney, K. Lin, G. Breen, R. Wroe, A.W. To, K. Leroy, M. Causevic, A. Usardi, M. Robinson, W. Noble, R. Williamson, K. Lunnon, S. Kellie, C.H. Reynolds, C. Bazenet, A. Hodges, J.P. Brion, J. Stephenson, J.P. Simons, and S. Lovestone. (2014). Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry, 19(1), 88-98.<\/p>\r\n\r\n\r\n\r\n
56.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Trougakos, I.P., M. Lourda, M.H. Antonelou, D. Kletsas, V.G. Gorgoulis, I.S. Papassideri, Y. Zou, L.H. Margaritis, D.A. Boothman, and E.S. Gonos. (2009). Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res, 15(1), 48-59.<\/p>\r\n\r\n\r\n\r\n
57.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Zhang, H., J.K. Kim, C.A. Edwards, Z. Xu, R. Taichman, and C.Y. Wang. (2005). Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol, 7(9), 909-15.<\/p>\r\n\r\n\r\n\r\n
58.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Morgan, T.E., N.J. Laping, I. Rozovsky, T. Oda, T.H. Hogan, C.E. Finch, and G.M. Pasinetti. (1995). Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. J Neuroimmunol, 58(1), 101-10.<\/p>\r\n\r\n\r\n\r\n
59.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Rizzi, F., M. Coletta, and S. Bettuzzi. (2009). Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins. Adv Cancer Res, 104, 9-23.<\/p>\r\n\r\n\r\n\r\n
60.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Uddin, M.S., M.T. Kabir, M.M. Begum, M.S. Islam, T. Behl, and G.M. Ashraf. (2021). Exploring the Role of CLU in the Pathogenesis of Alzheimer’s Disease. Neurotox Res, 39(6), 2108-2119.<\/p>\r\n\r\n\r\n\r\n
61.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kim, N., J.C. Yoo, J.Y. Han, E.M. Hwang, Y.S. Kim, E.Y. Jeong, C.H. Sun, G.S. Yi, G.S. Roh, H.J. Kim, S.S. Kang, G.J. Cho, J.Y. Park, and W.S. Choi. (2012). Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J Cell Physiol, 227(3), 1157-67.<\/p>\r\n\r\n\r\n\r\n
62.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Scaltriti, M., S. Bettuzzi, R.M. Sharrard, A. Caporali, A.E. Caccamo, and N.J. Maitland. (2004). Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis. Br J Cancer, 91(10), 1842-50.<\/p>\r\n\r\n\r\n\r\n
63.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Scaltriti, M., A. Santamaria, R. Paciucci, and S. Bettuzzi. (2004). Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1. Cancer Res, 64(17), 6174-82.<\/p>\r\n\r\n\r\n\r\n
64.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Takase, O., A.W. Minto, T.S. Puri, P.N. Cunningham, A. Jacob, M. Hayashi, and R.J. Quigg. (2008). Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis. Kidney Int, 73(5), 567-77.<\/p>\r\n\r\n\r\n\r\n
65.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Yerbury, J.J., S. Poon, S. Meehan, B. Thompson, J.R. Kumita, C.M. Dobson, and M.R. Wilson. (2007). The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J, 21(10), 2312-22.<\/p>\r\n\r\n\r\n\r\n
66.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Wolozin, B. (2004). Cholesterol and the biology of Alzheimer’s disease. Neuron, 41(1), 7-10.<\/p>\r\n\r\n\r\n\r\n
67.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Di Paolo, G. and T.W. Kim. (2011). Linking lipids to Alzheimer’s disease: cholesterol and beyond. Nat Rev Neurosci, 12(5), 284-96.<\/p>\r\n\r\n\r\n\r\n
68.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jazvinscak Jembrek, M., P.R. Hof, and G. Simic. (2015). Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Abeta Accumulation. Oxid Med Cell Longev, 2015, 346783.<\/p>\r\n\r\n\r\n\r\n
69.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Zinser, E.G., T. Hartmann, and M.O. Grimm. (2007). Amyloid beta-protein and lipid metabolism. Biochim Biophys Acta, 1768(8), 1991-2001.<\/p>\r\n\r\n\r\n\r\n
70.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Bell, R.D., A.P. Sagare, A.E. Friedman, G.S. Bedi, D.M. Holtzman, R. Deane, and B.V. Zlokovic. (2007). Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab, 27(5), 909-18.<\/p>\r\n\r\n\r\n\r\n
71.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Yeh, F.L., Y. Wang, I. Tom, L.C. Gonzalez, and M. Sheng. (2016). TREM2 Binds to Apolipoproteins, Including APOE and CLU\/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron, 91(2), 328-40.<\/p>\r\n\r\n\r\n\r\n
72.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jenne, D.E. and J. Tschopp. (1989). Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. Proc Natl Acad Sci U S A, 86(18), 7123-7.<\/p>\r\n\r\n\r\n\r\n
73.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Murphy, B.F., J.R. Saunders, M.K. O’Bryan, L. Kirszbaum, I.D. Walker, and A.J. d’Apice. (1989). SP-40,40 is an inhibitor of C5b-6-initiated haemolysis. Int Immunol, 1(5), 551-4.<\/p>\r\n\r\n\r\n\r\n
74.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 McGeer, P.L., T. Kawamata, and D.G. Walker. (1992). Distribution of clusterin in Alzheimer brain tissue. Brain Res, 579(2), 337-41.<\/p>\r\n\r\n\r\n\r\n
75.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Caricasole, A., A. Copani, F. Caraci, E. Aronica, A.J. Rozemuller, A. Caruso, M. Storto, G. Gaviraghi, G.C. Terstappen, and F. Nicoletti. (2004). Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain. J Neurosci, 24(26), 6021-7.<\/p>\r\n\r\n\r\n\r\n
76.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Purro, S.A., E.M. Dickins, and P.C. Salinas. (2012). The secreted Wnt antagonist Dickkopf-1 is required for amyloid beta-mediated synaptic loss. J Neurosci, 32(10), 3492-8.<\/p>\r\n\r\n\r\n\r\n
77.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Thambisetty, M., A. Simmons, L. Velayudhan, A. Hye, J. Campbell, Y. Zhang, L.O. Wahlund, E. Westman, A. Kinsey, A. Guntert, P. Proitsi, J. Powell, M. Causevic, R. Killick, K. Lunnon, S. Lynham, M. Broadstock, F. Choudhry, D.R. Howlett, R.J. Williams, S.I. Sharp, C. Mitchelmore, C. Tunnard, R. Leung, C. Foy, D. O’Brien, G. Breen, S.J. Furney, M. Ward, I. Kloszewska, P. Mecocci, H. Soininen, M. Tsolaki, B. Vellas, A. Hodges, D.G. Murphy, S. Parkins, J.C. Richardson, S.M. Resnick, L. Ferrucci, D.F. Wong, Y. Zhou, S. Muehlboeck, A. Evans, P.T. Francis, C. Spenger, and S. Lovestone. (2010). Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry, 67(7), 739-48.<\/p>\r\n\r\n\r\n\r\n
78.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Shi, X., B. Xie, Y. Xing, and Y. Tang. (2019). Plasma Clusterin as a Potential Biomarker for Alzheimer’s Disease-A Systematic Review and Meta-analysis. Curr Alzheimer Res, 16(11), 1018-1027.<\/p>\r\n\r\n\r\n\r\n
79.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sakamuro, D., K.J. Elliott, R. Wechsler-Reya, and G.C. Prendergast. (1996). BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet, 14(1), 69-77.<\/p>\r\n\r\n\r\n\r\n
80.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 De Rossi, P., V. Buggia-Prevot, B.L. Clayton, J.B. Vasquez, C. van Sanford, R.J. Andrew, R. Lesnick, A. Botte, C. Deyts, S. Salem, E. Rao, R.C. Rice, A. Parent, S. Kar, B. Popko, P. Pytel, S. Estus, and G. Thinakaran. (2016). Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol Neurodegener, 11(1), 59.<\/p>\r\n\r\n\r\n\r\n
81.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Prokic, I., B.S. Cowling, and J. Laporte. (2014). Amphiphysin 2 (BIN1) in physiology and diseases. J Mol Med (Berl), 92(5), 453-63.<\/p>\r\n\r\n\r\n\r\n
82.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Gao, P., L. Ye, H. Cheng, and H. Li. (2021). The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer’s Disease. Cell Mol Neurobiol, 41(7), 1431-1440.<\/p>\r\n\r\n\r\n\r\n
83.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Wigge, P., K. Kohler, Y. Vallis, C.A. Doyle, D. Owen, S.P. Hunt, and H.T. McMahon. (1997). Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Mol Biol Cell, 8(10), 2003-15.<\/p>\r\n\r\n\r\n\r\n
84.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Harold, D., R. Abraham, P. Hollingworth, R. Sims, A. Gerrish, M.L. Hamshere, J.S. Pahwa, V. Moskvina, K. Dowzell, A. Williams, N. Jones, C. Thomas, A. Stretton, A.R. Morgan, S. Lovestone, J. Powell, P. Proitsi, M.K. Lupton, C. Brayne, D.C. Rubinsztein, M. Gill, B. Lawlor, A. Lynch, K. Morgan, K.S. Brown, P.A. Passmore, D. Craig, B. McGuinness, S. Todd, C. Holmes, D. Mann, A.D. Smith, S. Love, P.G. Kehoe, J. Hardy, S. Mead, N. Fox, M. Rossor, J. Collinge, W. Maier, F. Jessen, B. Schurmann, R. Heun, H. van den Bussche, I. Heuser, J. Kornhuber, J. Wiltfang, M. Dichgans, L. Frolich, H. Hampel, M. Hull, D. Rujescu, A.M. Goate, J.S. Kauwe, C. Cruchaga, P. Nowotny, J.C. Morris, K. Mayo, K. Sleegers, K. Bettens, S. Engelborghs, P.P. De Deyn, C. Van Broeckhoven, G. Livingston, N.J. Bass, H. Gurling, A. McQuillin, R. Gwilliam, P. Deloukas, A. Al-Chalabi, C.E. Shaw, M. Tsolaki, A.B. Singleton, R. Guerreiro, T.W. Muhleisen, M.M. Nothen, S. Moebus, K.H. Jockel, N. Klopp, H.E. Wichmann, M.M. Carrasquillo, V.S. Pankratz, S.G. Younkin, P.A. Holmans, M. O’Donovan, M.J. Owen, and J. Williams. (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet, 41(10), 1088-93.<\/p>\r\n\r\n\r\n\r\n
85.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kunkle, B.W., B. Grenier-Boley, R. Sims, J.C. Bis, V. Damotte, A.C. Naj, A. Boland, M. Vronskaya, S.J. van der Lee, A. Amlie-Wolf, C. Bellenguez, A. Frizatti, V. Chouraki, E.R. Martin, K. Sleegers, N. Badarinarayan, J. Jakobsdottir, K.L. Hamilton-Nelson, S. Moreno-Grau, R. Olaso, R. Raybould, Y. Chen, A.B. Kuzma, M. Hiltunen, T. Morgan, S. Ahmad, B.N. Vardarajan, J. Epelbaum, P. Hoffmann, M. Boada, G.W. Beecham, J.G. Garnier, D. Harold, A.L. Fitzpatrick, O. Valladares, M.L. Moutet, A. Gerrish, A.V. Smith, L. Qu, D. Bacq, N. Denning, X. Jian, Y. Zhao, M. Del Zompo, N.C. Fox, S.H. Choi, I. Mateo, J.T. Hughes, H.H. Adams, J. Malamon, F. Sanchez-Garcia, Y. Patel, J.A. Brody, B.A. Dombroski, M.C.D. Naranjo, M. Daniilidou, G. Eiriksdottir, S. Mukherjee, D. Wallon, J. Uphill, T. Aspelund, L.B. Cantwell, F. Garzia, D. Galimberti, E. Hofer, M. Butkiewicz, B. Fin, E. Scarpini, C. Sarnowski, W.S. Bush, S. Meslage, J. Kornhuber, C.C. White, Y. Song, R.C. Barber, S. Engelborghs, S. Sordon, D. Voijnovic, P.M. Adams, R. Vandenberghe, M. Mayhaus, L.A. Cupples, M.S. Albert, P.P. De Deyn, W. Gu, J.J. Himali, D. Beekly, A. Squassina, A.M. Hartmann, A. Orellana, D. Blacker, E. Rodriguez-Rodriguez, S. Lovestone, M.E. Garcia, R.S. Doody, C. Munoz-Fernadez, R. Sussams, H. Lin, T.J. Fairchild, Y.A. Benito, C. Holmes, H. Karamujic-Comic, M.P. Frosch, H. Thonberg, W. Maier, G. Roshchupkin, B. Ghetti, V. Giedraitis, A. Kawalia, S. Li, R.M. Huebinger, L. Kilander, S. Moebus, I. Hernandez, M.I. Kamboh, R. Brundin, J. Turton, Q. Yang, M.J. Katz, L. Concari, J. Lord, A.S. Beiser, C.D. Keene, S. Helisalmi, I. Kloszewska, W.A. Kukull, A.M. Koivisto, A. Lynch, L. Tarraga, E.B. Larson, A. Haapasalo, B. Lawlor, T.H. Mosley, R.B. Lipton, V. Solfrizzi, M. Gill, W.T. Longstreth, Jr., T.J. Montine, V. Frisardi, M. Diez-Fairen, F. Rivadeneira, R.C. Petersen, V. Deramecourt, I. Alvarez, F. Salani, A. Ciaramella, E. Boerwinkle, E.M. Reiman, N. Fievet, J.I. Rotter, J.S. Reisch, O. Hanon, C. Cupidi, A.G. Andre Uitterlinden, D.R. Royall, C. Dufouil, R.G. Maletta, I. de Rojas, M. Sano, A. Brice, R. Cecchetti, P.S. George-Hyslop, K. Ritchie, M. Tsolaki, D.W. Tsuang, B. Dubois, D. Craig, C.K. Wu, H. Soininen, D. Avramidou, R.L. Albin, L. Fratiglioni, A. Germanou, L.G. Apostolova, L. Keller, M. Koutroumani, S.E. Arnold, F. Panza, O. Gkatzima, S. Asthana, D. Hannequin, P. Whitehead, C.S. Atwood, P. Caffarra, H. Hampel, I. Quintela, A. Carracedo, L. Lannfelt, D.C. Rubinsztein, L.L. Barnes, F. Pasquier, L. Frolich, S. Barral, B. McGuinness, T.G. Beach, J.A. Johnston, J.T. Becker, P. Passmore, E.H. Bigio, J.M. Schott, T.D. Bird, J.D. Warren, B.F. Boeve, M.K. Lupton, J.D. Bowen, P. Proitsi, A. Boxer, J.F. Powell, J.R. Burke, J.S.K. Kauwe, J.M. Burns, M. Mancuso, J.D. Buxbaum, U. Bonuccelli, N.J. Cairns, A. McQuillin, C. Cao, G. Livingston, C.S. Carlson, N.J. Bass, C.M. Carlsson, J. Hardy, R.M. Carney, J. Bras, M.M. Carrasquillo, R. Guerreiro, M. Allen, H.C. Chui, E. Fisher, C. Masullo, E.A. Crocco, C. DeCarli, G. Bisceglio, M. Dick, L. Ma, R. Duara, N.R. Graff-Radford, D.A. Evans, A. Hodges, K.M. Faber, M. Scherer, K.B. Fallon, M. Riemenschneider, D.W. Fardo, R. Heun, M.R. Farlow, H. Kolsch, S. Ferris, M. Leber, T.M. Foroud, I. Heuser, D.R. Galasko, I. Giegling, M. Gearing, M. Hull, D.H. Geschwind, J.R. Gilbert, J. Morris, R.C. Green, K. Mayo, J.H. Growdon, T. Feulner, R.L. Hamilton, L.E. Harrell, D. Drichel, L.S. Honig, T.D. Cushion, M.J. Huentelman, P. Hollingworth, C.M. Hulette, B.T. Hyman, R. Marshall, G.P. Jarvik, A. Meggy, E. Abner, G.E. Menzies, L.W. Jin, G. Leonenko, L.M. Real, G.R. Jun, C.T. Baldwin, D. Grozeva, A. Karydas, G. Russo, J.A. Kaye, R. Kim, F. Jessen, N.W. Kowall, B. Vellas, J.H. Kramer, E. Vardy, F.M. LaFerla, K.H. Jockel, J.J. Lah, M. Dichgans, J.B. Leverenz, D. Mann, A.I. Levey, S. Pickering-Brown, A.P. Lieberman, N. Klopp, K.L. Lunetta, H.E. Wichmann, C.G. Lyketsos, K. Morgan, D.C. Marson, K. Brown, F. Martiniuk, C. Medway, D.C. Mash, M.M. Nothen, E. Masliah, N.M. Hooper, W.C. McCormick, A. Daniele, S.M. McCurry, A. Bayer, A.N. McDavid, J. Gallacher, A.C. McKee, H. van den Bussche, M. Mesulam, C. Brayne, B.L. Miller, S. Riedel-Heller, C.A. Miller, J.W. Miller, A. Al-Chalabi, J.C. Morris, C.E. Shaw, A.J. Myers, J. Wiltfang, S. O’Bryant, J.M. Olichney, V. Alvarez, J.E. Parisi, A.B. Singleton, H.L. Paulson, J. Collinge, W.R. Perry, S. Mead, E. Peskind, D.H. Cribbs, M. Rossor, A. Pierce, N.S. Ryan, W.W. Poon, B. Nacmias, H. Potter, S. Sorbi, J.F. Quinn, E. Sacchinelli, A. Raj, G. Spalletta, M. Raskind, C. Caltagirone, P. Bossu, M.D. Orfei, B. Reisberg, R. Clarke, C. Reitz, A.D. Smith, J.M. Ringman, D. Warden, E.D. Roberson, G. Wilcock, E. Rogaeva, A.C. Bruni, H.J. Rosen, M. Gallo, R.N. Rosenberg, Y. Ben-Shlomo, M.A. Sager, P. Mecocci, A.J. Saykin, P. Pastor, M.L. Cuccaro, J.M. Vance, J.A. Schneider, L.S. Schneider, S. Slifer, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, M. Tang, R.E. Tanzi, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh-Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C.E. Yu, L. Yu, Y. Saba, A. Pilotto, M.J. Bullido, O. Peters, P.K. Crane, D. Bennett, P. Bosco, E. Coto, V. Boccardi, P.L. De Jager, A. Lleo, N. Warner, O.L. Lopez, M. Ingelsson, P. Deloukas, C. Cruchaga, C. Graff, R. Gwilliam, M. Fornage, A.M. Goate, P. Sanchez-Juan, P.G. Kehoe, N. Amin, N. Ertekin-Taner, C. Berr, S. Debette, S. Love, L.J. Launer, S.G. Younkin, J.F. Dartigues, C. Corcoran, M.A. Ikram, D.W. Dickson, G. Nicolas, D. Campion, J. Tschanz, H. Schmidt, H. Hakonarson, J. Clarimon, R. Munger, R. Schmidt, L.A. Farrer, C. Van Broeckhoven, C.O.D. M, A.L. DeStefano, L. Jones, J.L. Haines, J.F. Deleuze, M.J. Owen, V. Gudnason, R. Mayeux, V. Escott-Price, B.M. Psaty, A. Ramirez, L.S. Wang, A. Ruiz, C.M. van Duijn, P.A. Holmans, S. Seshadri, J. Williams, P. Amouyel, G.D. Schellenberg, J.C. Lambert, M.A. Pericak-Vance, C. Alzheimer Disease Genetics, I. European Alzheimer’s Disease, H. Cohorts for, C. Aging Research in Genomic Epidemiology, Genetic, P. Environmental Risk in Ad\/Defining Genetic and C. Environmental Risk for Alzheimer’s Disease. (2019). Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nat Genet, 51(3), 414-430.<\/p>\r\n\r\n\r\n\r\n
86.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lambert, J.C., C.A. Ibrahim-Verbaas, D. Harold, A.C. Naj, R. Sims, C. Bellenguez, A.L. DeStafano, J.C. Bis, G.W. Beecham, B. Grenier-Boley, G. Russo, T.A. Thorton-Wells, N. Jones, A.V. Smith, V. Chouraki, C. Thomas, M.A. Ikram, D. Zelenika, B.N. Vardarajan, Y. Kamatani, C.F. Lin, A. Gerrish, H. Schmidt, B. Kunkle, M.L. Dunstan, A. Ruiz, M.T. Bihoreau, S.H. Choi, C. Reitz, F. Pasquier, C. Cruchaga, D. Craig, N. Amin, C. Berr, O.L. Lopez, P.L. De Jager, V. Deramecourt, J.A. Johnston, D. Evans, S. Lovestone, L. Letenneur, F.J. Moron, D.C. Rubinsztein, G. Eiriksdottir, K. Sleegers, A.M. Goate, N. Fievet, M.W. Huentelman, M. Gill, K. Brown, M.I. Kamboh, L. Keller, P. Barberger-Gateau, B. McGuiness, E.B. Larson, R. Green, A.J. Myers, C. Dufouil, S. Todd, D. Wallon, S. Love, E. Rogaeva, J. Gallacher, P. St George-Hyslop, J. Clarimon, A. Lleo, A. Bayer, D.W. Tsuang, L. Yu, M. Tsolaki, P. Bossu, G. Spalletta, P. Proitsi, J. Collinge, S. Sorbi, F. Sanchez-Garcia, N.C. Fox, J. Hardy, M.C. Deniz Naranjo, P. Bosco, R. Clarke, C. Brayne, D. Galimberti, M. Mancuso, F. Matthews, I. European Alzheimer’s Disease, Genetic, D. Environmental Risk in Alzheimer’s, C. Alzheimer’s Disease Genetic, H. Cohorts for, E. Aging Research in Genomic, S. Moebus, P. Mecocci, M. Del Zompo, W. Maier, H. Hampel, A. Pilotto, M. Bullido, F. Panza, P. Caffarra, B. Nacmias, J.R. Gilbert, M. Mayhaus, L. Lannefelt, H. Hakonarson, S. Pichler, M.M. Carrasquillo, M. Ingelsson, D. Beekly, V. Alvarez, F. Zou, O. Valladares, S.G. Younkin, E. Coto, K.L. Hamilton-Nelson, W. Gu, C. Razquin, P. Pastor, I. Mateo, M.J. Owen, K.M. Faber, P.V. Jonsson, O. Combarros, M.C. O’Donovan, L.B. Cantwell, H. Soininen, D. Blacker, S. Mead, T.H. Mosley, Jr., D.A. Bennett, T.B. Harris, L. Fratiglioni, C. Holmes, R.F. de Bruijn, P. Passmore, T.J. Montine, K. Bettens, J.I. Rotter, A. Brice, K. Morgan, T.M. Foroud, W.A. Kukull, D. Hannequin, J.F. Powell, M.A. Nalls, K. Ritchie, K.L. Lunetta, J.S. Kauwe, E. Boerwinkle, M. Riemenschneider, M. Boada, M. Hiltuenen, E.R. Martin, R. Schmidt, D. Rujescu, L.S. Wang, J.F. Dartigues, R. Mayeux, C. Tzourio, A. Hofman, M.M. Nothen, C. Graff, B.M. Psaty, L. Jones, J.L. Haines, P.A. Holmans, M. Lathrop, M.A. Pericak-Vance, L.J. Launer, L.A. Farrer, C.M. van Duijn, C. Van Broeckhoven, V. Moskvina, S. Seshadri, J. Williams, G.D. Schellenberg and P. Amouyel. (2013). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet, 45(12), 1452-8.<\/p>\r\n\r\n\r\n\r\n
87.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Seshadri, S., A.L. Fitzpatrick, M.A. Ikram, A.L. DeStefano, V. Gudnason, M. Boada, J.C. Bis, A.V. Smith, M.M. Carassquillo, J.C. Lambert, D. Harold, E.M. Schrijvers, R. Ramirez-Lorca, S. Debette, W.T. Longstreth, Jr., A.C. Janssens, V.S. Pankratz, J.F. Dartigues, P. Hollingworth, T. Aspelund, I. Hernandez, A. Beiser, L.H. Kuller, P.J. Koudstaal, D.W. Dickson, C. Tzourio, R. Abraham, C. Antunez, Y. Du, J.I. Rotter, Y.S. Aulchenko, T.B. Harris, R.C. Petersen, C. Berr, M.J. Owen, J. Lopez-Arrieta, B.N. Varadarajan, J.T. Becker, F. Rivadeneira, M.A. Nalls, N.R. Graff-Radford, D. Campion, S. Auerbach, K. Rice, A. Hofman, P.V. Jonsson, H. Schmidt, M. Lathrop, T.H. Mosley, R. Au, B.M. Psaty, A.G. Uitterlinden, L.A. Farrer, T. Lumley, A. Ruiz, J. Williams, P. Amouyel, S.G. Younkin, P.A. Wolf, L.J. Launer, O.L. Lopez, C.M. van Duijn, M.M. Breteler, C. Consortium, G. Consortium, and E. Consortium. (2010). Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA, 303(18), 1832-40.<\/p>\r\n\r\n\r\n\r\n
88.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Calafate, S., W. Flavin, P. Verstreken, and D. Moechars. (2016). Loss of Bin1 Promotes the Propagation of Tau Pathology. Cell Rep, 17(4), 931-940.<\/p>\r\n\r\n\r\n\r\n
89.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyagawa, T., I. Ebinuma, Y. Morohashi, Y. Hori, M. Young Chang, H. Hattori, T. Maehara, S. Yokoshima, T. Fukuyama, S. Tsuji, T. Iwatsubo, G.C. Prendergast, and T. Tomita. (2016). BIN1 regulates BACE1 intracellular trafficking and amyloid-beta production. Hum Mol Genet, 25(14), 2948-2958.<\/p>\r\n\r\n\r\n\r\n
90.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Karch, C.M., A.T. Jeng, P. Nowotny, J. Cady, C. Cruchaga, and A.M. Goate. (2012). Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains. PLoS One, 7(11), e50976.<\/p>\r\n\r\n\r\n\r\n
91.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Holler, C.J., P.R. Davis, T.L. Beckett, T.L. Platt, R.L. Webb, E. Head, and M.P. Murphy. (2014). Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer’s disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis, 42(4), 1221-7.<\/p>\r\n\r\n\r\n\r\n
92.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sottejeau, Y., A. Bretteville, F.X. Cantrelle, N. Malmanche, F. Demiaute, T. Mendes, C. Delay, H. Alves Dos Alves, A. Flaig, P. Davies, P. Dourlen, B. Dermaut, J. Laporte, P. Amouyel, G. Lippens, J. Chapuis, I. Landrieu, and J.C. Lambert. (2015). Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain. Acta Neuropathol Commun, 3, 58.<\/p>\r\n\r\n\r\n\r\n
93.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ubelmann, F., T. Burrinha, L. Salavessa, R. Gomes, C. Ferreira, N. Moreno, and C. Guimas Almeida. (2017). Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep, 18(1), 102-122.<\/p>\r\n\r\n\r\n\r\n
94.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Andrew, R.J., P. De Rossi, P. Nguyen, H.R. Kowalski, A.J. Recupero, T. Guerbette, S.V. Krause, R.C. Rice, L. Laury-Kleintop, S.L. Wagner, and G. Thinakaran. (2019). Reduction of the expression of the late-onset Alzheimer’s disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem, 294(12), 4477-4487.<\/p>\r\n\r\n\r\n\r\n
95.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Crotti, A., H.R. Sait, K.M. McAvoy, K. Estrada, A. Ergun, S. Szak, G. Marsh, L. Jandreski, M. Peterson, T.L. Reynolds, I. Dalkilic-Liddle, A. Cameron, E. Cahir-McFarland, and R.M. Ransohoff. (2019). BIN1 favors the spreading of Tau via extracellular vesicles. Sci Rep, 9(1), 9477.<\/p>\r\n\r\n\r\n\r\n
96.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 McAvoy, K.M., H. Rajamohamed Sait, G. Marsh, M. Peterson, T.L. Reynolds, J. Gagnon, S. Geisler, P. Leach, C. Roberts, E. Cahir-McFarland, R.M. Ransohoff, and A. Crotti. (2019). Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PLoS One, 14(8), e0220125.<\/p>\r\n\r\n\r\n\r\n
97.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Iruela-Arispe, M.L., D. Carpizo, and A. Luque. (2003). ADAMTS1: a matrix metalloprotease with angioinhibitory properties. Ann N Y Acad Sci, 995, 183-90.<\/p>\r\n\r\n\r\n\r\n
98.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jantti, H., V. Sitnikova, Y. Ishchenko, A. Shakirzyanova, L. Giudice, I.F. Ugidos, M. Gomez-Budia, N. Korvenlaita, S. Ohtonen, I. Belaya, F. Fazaludeen, N. Mikhailov, M. Gotkiewicz, K. Ketola, S. Lehtonen, J. Koistinaho, K.M. Kanninen, D. Hernandez, A. Pebay, R. Giugno, P. Korhonen, R. Giniatullin, and T. Malm. (2022). Microglial amyloid beta clearance is driven by PIEZO1 channels. J Neuroinflammation, 19(1), 147.<\/p>\r\n\r\n\r\n\r\n
99.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Schwartzentruber, J., S. Cooper, J.Z. Liu, I. Barrio-Hernandez, E. Bello, N. Kumasaka, A.M.H. Young, R.J.M. Franklin, T. Johnson, K. Estrada, D.J. Gaffney, P. Beltrao, and A. Bassett. (2021). Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes. Nat Genet, 53(3), 392-402.<\/p>\r\n\r\n\r\n\r\n
100.\u00a0\u00a0\u00a0\u00a0 Beher, D., L. Hesse, C.L. Masters, and G. Multhaup. (1996). Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem, 271(3), 1613-20.<\/p>\r\n\r\n\r\n\r\n
101.\u00a0\u00a0\u00a0\u00a0 Caceres, J. and E. Brandan. (1997). Interaction between Alzheimer’s disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. J Cell Biochem, 65(2), 145-58.<\/p>\r\n\r\n\r\n\r\n
102.\u00a0\u00a0\u00a0\u00a0 van der Kant, R. and L.S. Goldstein. (2015). Cellular functions of the amyloid precursor protein from development to dementia. Dev Cell, 32(4), 502-15.<\/p>\r\n\r\n\r\n\r\n
103.\u00a0\u00a0\u00a0\u00a0 Qiu, Y., L. Sha, X. Zhang, G. Li, W. Zhu, and Q. Xu. (2022). Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-beta and consequent Alzheimer’s disease risk. Front Aging Neurosci, 14, 896522.<\/p>\r\n\r\n\r\n\r\n
104.\u00a0\u00a0\u00a0\u00a0 Buggia-Prevot, V., C.G. Fernandez, V. Udayar, K.S. Vetrivel, A. Elie, J. Roseman, V.A. Sasse, M. Lefkow, X. Meckler, S. Bhattacharyya, M. George, S. Kar, V.P. Bindokas, A.T. Parent, L. Rajendran, H. Band, R. Vassar, and G. Thinakaran. (2013). A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer’s disease Abeta production. Cell Rep, 5(6), 1552-63.<\/p>\r\n\r\n\r\n\r\n
105.\u00a0\u00a0\u00a0\u00a0 Sannerud, R., I. Declerck, A. Peric, T. Raemaekers, G. Menendez, L. Zhou, B. Veerle, K. Coen, S. Munck, B. De Strooper, G. Schiavo, and W. Annaert. (2011). ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A, 108(34), E559-68.<\/p>\r\n\r\n\r\n\r\n
106.\u00a0\u00a0\u00a0\u00a0 Yi, C., K.Y. Goh, L.W. Wong, A. Ramanujan, K. Tanaka, S. Sajikumar, and C.F. Ibanez. (2021). Inactive variants of death receptor p75(NTR) reduce Alzheimer’s neuropathology by interfering with APP internalization. EMBO J, 40(2), e104450.<\/p>\r\n\r\n\r\n\r\n
107.\u00a0\u00a0\u00a0\u00a0 Brocker, C.N., V. Vasiliou, and D.W. Nebert. (2009). Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Hum Genomics, 4(1), 43-55.<\/p>\r\n\r\n\r\n\r\n
108.\u00a0\u00a0\u00a0\u00a0 Greening, D.W., S.K. Gopal, R.A. Mathias, L. Liu, J. Sheng, H.J. Zhu, and R.J. Simpson. (2015). Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression. Semin Cell Dev Biol, 40, 60-71.<\/p>\r\n\r\n\r\n\r\n
109.\u00a0\u00a0\u00a0\u00a0 Shimoda, M., T. Ohtsuka, Y. Okada, and Y. Kanai. (2021). Stromal metalloproteinases: Crucial contributors to the tumor microenvironment. Pathol Int, 71(1), 1-14.<\/p>\r\n\r\n\r\n\r\n
110.\u00a0\u00a0\u00a0\u00a0 Gallo, F.T., C. Katche, J.F. Morici, J.H. Medina, and N.V. Weisstaub. (2018). Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc. Front Behav Neurosci, 12, 79.<\/p>\r\n","protected":false},"excerpt":{"rendered":"
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