{"id":290,"date":"2017-12-04T11:27:44","date_gmt":"2017-12-04T10:27:44","guid":{"rendered":"https:\/\/www.iemest.eu\/liss\/?p=290"},"modified":"2021-01-13T11:44:06","modified_gmt":"2021-01-13T10:44:06","slug":"the-new-era-of-non-coding-rnas-the-state-of-art-and-future-perspectives-in-advanced-molecular-therapiesthe-new-era-of-non-coding-rnas-the-state-of-art-and-future-perspectives-in-advanced-molecular-t","status":"publish","type":"post","link":"https:\/\/www.iemest.eu\/life-safety-and-security\/2017\/12\/04\/the-new-era-of-non-coding-rnas-the-state-of-art-and-future-perspectives-in-advanced-molecular-therapiesthe-new-era-of-non-coding-rnas-the-state-of-art-and-future-perspectives-in-advanced-molecular-t\/","title":{"rendered":"The New Era Of Non-Coding RNAs: The State Of Art And Future Perspectives In Advanced Molecular Therapiesthe New Era Of Non-Coding Rnas: The State Of Art And Future Perspectives In Advanced Molecular Therapies"},"content":{"rendered":"\n

Luigi Donato, Concetta Scimone, Simona Alibrandi, Rosalia D\u2019Angelo, Antonina Sidoti<\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

The most of chronic and common pathologies represent the result of intricate and heterogeneous causes, from heritable components to environmental elements. This complex picture represents a strong challenge towards the acknowledgement of diseases etiology, which could be fight by discovery and use of disease predisposing alleles. This purpose could be realized using many genetic tests, which could facilitate early treatment, preemptive selection of efficacious drugs, and more accurate estimation of risk, because severity and response to cure reflects the underlying individual allelic picture. But, if the effective advantages of such model are relevant for monogenic disorders, more complex results the situation for polygenic ones, as Retinitis pigmentosa and Cerebral Cavernous Malformations. Moreover, elements like lifestyle and environment, risk of false positive or negative, and accessibility to analysis data make the results and risks determined by predictive medicine more difficult to quantify. Finally, prediction could represent the future of translational research.<\/p>\n\n\n\n

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Luigi Donato, Concetta Scimone, Simona Alibrandi, Rosalia D\u2019Angelo, Antonina Sidoti Abstract The most of chronic and common pathologies represent the result of intricate and heterogeneous<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[116,115,117],"class_list":["post-290","post","type-post","status-publish","format-standard","hentry","category-minireview","tag-ngs","tag-polymorphisms","tag-prediction-models"],"_links":{"self":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/290","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/comments?post=290"}],"version-history":[{"count":2,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/290\/revisions"}],"predecessor-version":[{"id":292,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/290\/revisions\/292"}],"wp:attachment":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/media?parent=290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/categories?post=290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/tags?post=290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}