{"id":274,"date":"2017-08-09T11:01:25","date_gmt":"2017-08-09T09:01:25","guid":{"rendered":"https:\/\/www.iemest.eu\/liss\/?p=274"},"modified":"2021-01-13T11:48:30","modified_gmt":"2021-01-13T10:48:30","slug":"role-of-prostaglandins-and-ultrasound-debridement-in-healing-of-septic-ulcers-and-fistula-complication-of-prostheses-in-osteomyelitis-infected-knee","status":"publish","type":"post","link":"https:\/\/www.iemest.eu\/life-safety-and-security\/2017\/08\/09\/role-of-prostaglandins-and-ultrasound-debridement-in-healing-of-septic-ulcers-and-fistula-complication-of-prostheses-in-osteomyelitis-infected-knee\/","title":{"rendered":"Role Of Prostaglandins And Ultrasound Debridement In Healing Of Septic Ulcers And Fistula \u2013 Complication Of Prostheses In Osteomyelitis Infected Knee"},"content":{"rendered":"\n<p>Erminia Bentivegna, Luigi Donato, Concetta Scimone, Vivaldi Roberto, Mularo Salvatore, Citarrella Emanuele, Mavaro Giuseppe, Rosalia D\u2019Angelo, Antonina Sidoti<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p>Implant of devices in patients affected by serious osteoporosis following chronical inflammatory diseases like rheumatoid arthritis represent a great clinic and surgical challenge, especially when associated with bacterial infections. Here we report a case of a 75 years old woman who developed recidivism of infection, after prosthesis\u2019 implantation. Although repeated treatments with both topical antibiotics and systemic ones, knee edema and purulent secretion were constant.Conventional treatment based on topical and systemic antibiotics\u2019 administration was replaced with a vascular rehabilitative medical therapy. Furthermore, the patient has undergone surgery for ulcers and fistulas debridement at the knee, the lower third of thigh and the upper third of leg. The analyzed case suggested that the experimental protocol we used to treat implant \u2013 derived osteomyelitis with cutaneous fistulization could reduce the healing time between the primary lesion and osteomyelitis complication, but only if patient presents an acceptable condition of his immune system.<\/p>\n\n\n\n<p>References<\/p>\n\n\n\n<p>1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Springer\nBD, Cahue S, Etkin CD, Lewallen DG, McGrory BJ: <strong>Infection burden in total hip and knee arthroplasties: an international\nregistry-based perspective.<\/strong> <em>Arthroplast\nToday <\/em>2017, <strong>3:<\/strong>137-140.<\/p>\n\n\n\n<p>2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Geurts J,\nHohnen A, Vranken T, Moh P: <strong>Treatment\nstrategies for chronic osteomyelitis in low and middle income countries:\nSystematic review.<\/strong> <em>Trop Med Int\nHealth <\/em>2017.<\/p>\n\n\n\n<p>3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Jaramillo D,\nDormans JP, Delgado J, Laor T, St Geme JW, 3rd: <strong>Hematogenous Osteomyelitis in Infants and Children: Imaging of a\nChanging Disease.<\/strong> <em>Radiology <\/em>2017,\n<strong>283:<\/strong>629-643.<\/p>\n\n\n\n<p>4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lalikian K,\nParsiani R, Won R, Chang E, Turner RB: <strong>Ceftaroline\nfor the treatment of osteomyelitis caused by methicillin-resistant\nStaphylococcus aureus: a case series.<\/strong> <em>J\nChemother <\/em>2017<strong>:<\/strong>1-5.<\/p>\n\n\n\n<p>5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Ata Y, Inaba\nY, Choe H, Kobayashi N, Machida J, Nakamura N, Saito T: <strong>Bone metabolism and inflammatory characteristics in 14 cases of chronic\nnonbacterial osteomyelitis.<\/strong> <em>Pediatr\nRheumatol Online J <\/em>2017, <strong>15:<\/strong>56.<\/p>\n\n\n\n<p>6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Zimmerli W,\nSendi P: <strong>Orthopaedic biofilm infections.<\/strong>\n<em>APMIS <\/em>2017, <strong>125:<\/strong>353-364.<\/p>\n\n\n\n<p>7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Iliadis AD,\nRamachandran M: <strong>Paediatric bone and\njoint infection.<\/strong> <em>EFORT Open Rev <\/em>2017,\n<strong>2:<\/strong>7-12.<\/p>\n\n\n\n<p>8.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Kim BK, Dan\nJ, Lee YS, Kim SH, Cha YS: <strong>Salmonella\nosteomyelitis of the femoral diaphysis in a healthy individual.<\/strong> <em>Am J Orthop (Belle Mead NJ) <\/em>2014, <strong>43:<\/strong>E237-239.<\/p>\n\n\n\n<p>9.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Rowson C,\nTownsend R: <strong>Biofilms: prevention and\ntreatment.<\/strong> <em>Br J Hosp Med (Lond) <\/em>2016,\n<strong>77:<\/strong>699-703.<\/p>\n\n\n\n<p>10.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Bentivegna E,\nCitarrella E, Vivaldi R, De Luca D, Maira GG, Casuccio A, Di Carlo P: <strong>Leg ulcer and osteomyelitis due to\nmethicillin-susceptible Staphylococcus aureus infection after fracture repair\ntreatment: a case highlighting the potential role of prostaglandin E(1)\nvasodilator.<\/strong> <em>Infez Med <\/em>2015, <strong>23:<\/strong>69-73.<\/p>\n\n\n\n<p>11.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Johansen LK,\nIburg TM, Nielsen OL, Leifsson PS, Dahl-Petersen K, Koch J, Frees D, Aalbaek B,\nHeegaard PM, Jensen HE: <strong>Local osteogenic\nexpression of cyclooxygenase-2 and systemic response in porcine models of\nosteomyelitis.<\/strong> <em>Prostaglandins Other\nLipid Mediat <\/em>2012, <strong>97:<\/strong>103-108.<\/p>\n\n\n\n<p>12.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Hall JA,\nBeuerlein MJ, McKee MD, Canadian Orthopaedic Trauma S: <strong>Open reduction and internal fixation compared with circular fixator\napplication for bicondylar tibial plateau fractures. Surgical technique.<\/strong> <em>J Bone Joint Surg Am <\/em>2009, <strong>91 Suppl 2 Pt 1:<\/strong>74-88.<\/p>\n\n\n\n<p>13.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Govaert GA,\nGlaudemans AW, Ploegmakers JJ, Viddeleer AR, Wendt KW, Reininga IH: <strong>Diagnostic strategies for posttraumatic\nosteomyelitis: a survey amongst Dutch medical specialists demonstrates the need\nfor a consensus protocol.<\/strong> <em>Eur J\nTrauma Emerg Surg <\/em>2017.<\/p>\n\n\n\n<p>14.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Wagner JM,\nJaurich H, Wallner C, Abraham S, Becerikli M, Dadras M, Harati K, Duhan V,\nKhairnar V, Lehnhardt M, Behr B: <strong>Diminished\nbone regeneration after debridement of posttraumatic osteomyelitis is\naccompanied by altered cytokine levels, elevated B cell activity, and increased\nosteoclast activity.<\/strong> <em>J Orthop Res <\/em>2017.<\/p>\n\n\n\n<p>15.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Diniz MC,\nOlivon VC, Tavares LD, Simplicio JA, Gonzaga NA, de Souza DG, Bendhack LM,\nTirapelli CR, Bonaventura D: <strong>Mechanisms\nunderlying sodium nitroprusside-induced tolerance in the mouse aorta: Role of\nROS and cyclooxygenase-derived prostanoids.<\/strong> <em>Life Sci <\/em>2017, <strong>176:<\/strong>26-34.<\/p>\n\n\n\n<p>16.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lovati AB,\nRomano CL, Monti L, Vassena C, Previdi S, Drago L: <strong>Does PGE(1) vasodilator prevent orthopaedic implant-related infection\nin diabetes? Preliminary results in a mouse model.<\/strong> <em>PLoS One <\/em>2014, <strong>9:<\/strong>e94758.<\/p>\n\n\n\n<p>17.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lironi C,\nMcLin VA, Wildhaber BE: <strong>The Effect and\nSafety of Prostaglandin Administration in Pediatric Liver Transplantation.<\/strong> <em>Transplant Direct <\/em>2017, <strong>3:<\/strong>e163.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Erminia Bentivegna, Luigi Donato, Concetta Scimone, Vivaldi Roberto, Mularo Salvatore, Citarrella Emanuele, Mavaro Giuseppe, Rosalia D\u2019Angelo, Antonina Sidoti Abstract Implant of devices in patients affected<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[89,87,86,88],"class_list":["post-274","post","type-post","status-publish","format-standard","hentry","category-original-paper","tag-immune-system","tag-implants","tag-osteomyelitis","tag-prostaglandins"],"_links":{"self":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/comments?post=274"}],"version-history":[{"count":1,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/274\/revisions"}],"predecessor-version":[{"id":275,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/274\/revisions\/275"}],"wp:attachment":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/media?parent=274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/categories?post=274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/tags?post=274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}