{"id":259,"date":"2018-11-30T09:44:58","date_gmt":"2018-11-30T08:44:58","guid":{"rendered":"https:\/\/www.iemest.eu\/liss\/?p=259"},"modified":"2021-01-13T09:52:20","modified_gmt":"2021-01-13T08:52:20","slug":"gut-microbiota-in-metabolic-and-inflammatory-diseases","status":"publish","type":"post","link":"https:\/\/www.iemest.eu\/life-safety-and-security\/2018\/11\/30\/gut-microbiota-in-metabolic-and-inflammatory-diseases\/","title":{"rendered":"Gut Microbiota In Metabolic And Inflammatory Diseases"},"content":{"rendered":"\n

Concetta Scimone, Luigi Donato, Simona Alibrandi, Rosalia D\u2019Angelo, Antonina Sidoti<\/p>\n\n\n\n

Abstract<\/strong><\/p>\n\n\n\n

Human body is colonized by more than 5000 different bacteria species living in symbiosis with the host. Most of them, however, inhabit intestinal tract and perform vital functions for the host, as metabolism, differentiation of gut epithelium, modulation of immune system. Many factors can influence equilibrium of normal flora and, among these, host genetic features, nutrients, lifestyle. Pathogenesis of several bowel and metabolic disorders is not well elucidated. Application of omics sciences for molecular characterization of gut microbiota is proving the high impact of gastrointestinal bacteria in development of inflammatory bowel diseases, as Crohn disease, and metabolic disorders, like diabetes mellitus and obesity. Here we focused on the main pathological conditions, with particular attention to the role of microbiota. <\/p>\n\n\n\n

References <\/strong><\/p>\n\n\n\n

  1. Kho\nZY, Lal SK. The Human Gut Microbiome – A Potential Controller of Wellness and\nDisease. Front Microbiol 2018;9:1835<\/li>
  2. Pickard\nJM, Zeng MY, Caruso R, N\u00fa\u00f1ez G. Gut microbiota: Role in pathogen colonization,\nimmune responses, and inflammatory disease. Immunol Rev 2017;279:70-89<\/li>
  3. Khlevner\nJ, Park Y, Margolis KG. Brain-Gut Axis: Clinical Implications. Gastroenterol\nClin North Am 2018;47:727-39<\/li>
  4. D\u0105browska\nK, Witkiewicz W. Correlations of Host Genetics and Gut Microbiome Composition.\nFront Microbiol 2016;7:1357<\/li>
  5. Yu\nLC. Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease\nand colorectal cancers: exploring a common ground hypothesis. J Biomed Sci\n2018;25:79<\/li>
  6. Passos\nMDCF, Moraes-Filho JP. Intestinal microbiota in digestive diseases. Arq\nGastroenterol 2017;54:255-62<\/li>
  7. Peter\nJ, Fournier C, Keip B, Rittershaus N, Stephanou-Rieser N, Durdevic M, Dejaco C,\nMichalski M, Moser G. Intestinal Microbiome in Irritable Bowel Syndrome before\nand after Gut-Directed Hypnotherapy. Int J Mol Sci 2018;19.pii:E3619<\/li>
  8. Zuo\nT, Ng SC. The Gut Microbiota in the Pathogenesis and Therapeutics of\nInflammatory Bowel Disease. Front Microbiol 2018;9:2247<\/li>
  9. Vasiliauskas\nE. Recent advances in the diagnosis and classification of inflammatory bowel\ndisease. Curr Gastroenterol Rep 2003;5:493-500<\/li>
  10. Punchard\nNA. Overview: Nod2, cause of, or contributor to, Crohn’s disease. Curr Opin\nInvestig Drugs 2001;2:1378-81.<\/li>
  11. Wang\nMH, Picco MF. Crohn’s Disease: Genetics Update. Gastroenterol Clin North Am\n2017;46:449-61<\/li>
  12. Turnbaugh\nPJ, Gordon JI. The core gut microbiome, energy balance and obesity. J Physiol\n2009;587:4153-8<\/li>
  13. Vallianou\nNG, Stratigou T, Tsagarakis S. Microbiome and diabetes: Where are we now? Diabetes\nRes Clin Pract 2018;146:111-8<\/li>
  14. Sharma\nS, Tripathi P. Gut microbiome and type 2 diabetes: where we are and where to\ngo? J Nutr Biochem 2018;63:101-8<\/li>
  15. Chander\nAM, Yadav H, Jain S, Bhadada SK, Dhawan DK. Cross-Talk Between Gluten,\nIntestinal Microbiota and Intestinal Mucosa in Celiac Disease: Recent Advances\nand Basis of Autoimmunity. Front Microbiol 2018;9:2597<\/li>
  16. Yu\nLC, Wei SC, Ni YH. Impact of microbiota in colorectal carcinogenesis: lessons\nfrom experimental models. Intest Res 2018;16:346-57.<\/li>
  17. Yang\nY, Xu C, Wu D, Wang Z, Wu P, Li L, Huang J, Qiu F. \u03b3\u03b4 T Cells: Crosstalk\nBetween Microbiota, Chronic Inflammation, and Colorectal Cancer. Front Immunol\n2018;9:1483<\/li>
  18. Qiao\nYQ, Cai CW, Ran ZH. Therapeutic modulation of gut microbiota in inflammatory\nbowel disease: More questions to be answered. J Dig Dis 2016;17:800-10<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    Concetta Scimone, Luigi Donato, Simona Alibrandi, Rosalia D\u2019Angelo, Antonina Sidoti Abstract Human body is colonized by more than 5000 different bacteria species living in symbiosis<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[62,59,60,61],"class_list":["post-259","post","type-post","status-publish","format-standard","hentry","category-minireview","tag-bacterial-molecular-characterization","tag-gut-microbiota","tag-inflammatory-bowel-diseases","tag-metabolic-diseases"],"_links":{"self":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/comments?post=259"}],"version-history":[{"count":1,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/259\/revisions"}],"predecessor-version":[{"id":261,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/posts\/259\/revisions\/261"}],"wp:attachment":[{"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/media?parent=259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/categories?post=259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iemest.eu\/life-safety-and-security\/wp-json\/wp\/v2\/tags?post=259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}