Research involving animal studies

 

 

Animal research is defined as in vivo research performed on laboratory animals in order to develop knowledge that contributes to improvement of health and well-being of humans as well as other animals. The use of laboratory animals is often essential in biomedical research and humane and effective use of animals is a necessary and important element of such research activities. There is an important principle that all who care for, use, or produce animals for research, testing, or teaching must assume responsibility for their well-being.
For studies involving animals, all work must have been conducted according to applicable international guidelines of the ”Guide for the care and use of laboratory animals” of the National Research Council of the National Accademies press Washintong, DC, USA. The use of the Guide endorses the following principles:

  • consideration of alternatives (in vitro systems, computer simulations, and/or mathematical models) to reduce or replace the use of animals
  • design and performance of procedures on the basis of relevance to human or animal health, advancement of knowledge, or the good of society
  • use of appropriate species, quality, and number of animals
  • avoidance or minimization of discomfort, distress, and pain
  • use of appropriate sedation, analgesia, and anesthesia
  • establishment of humane endpoints
  • provision of adequate veterinary care
  • provision of appropriate animal transportation and husbandry directed and performed by qualified persons
  • conduct of experimentation on living animals exclusively by and/or under the close supervision of qualified and experienced personnel.

For cancer research with animal, the authors may find “Guidelines for the welfare and use of animals in cancer research”, Workman et al, (2010), helpful in this regard. This is a guidelines on the welfare and use of animals in cancer research, that, focusing on animal welfare, presents recommendations on all aspects of cancer research.
Prior approval must have been obtained for all protocols from the relevant author's institutional or other appropriate ethics committee, and the institution name and permit numbers must be provided at submission.
For research involving non-human primates, all studies must be performed in accordance with the recommendations of the Weatherall (2006) report, “The use of non-human primates in research”.

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Lo I.E.ME.S.T. presenta il GR.IN. Cluster al Green Conservation of Cultural Hertitage
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