International Projects

A Data Sharing Service for the Studies of the IAHCRC International Consortium on the Rare Diseases of the ATP1A3 Gene

IAHCRCFUNDERS: Patient Associations for Alternating Hemiplegia of Childhood (Cure AHC – USA, AHC Association of Iceland - Iceland, AHCUK – Great Britain, AHC Vereniging Nederland, Holland; IEMEST, Italy. Further co-funders would be desirable to ensure the sustainability of the Service (hosting, maintenance and development of new features) in the medium and long term.

AIMS: Implement an International Platform for the data collection and sharing for the collaborative studies of the Clinical and Basic Research Centers belonging to the International Consortium IAHCRC, involved in research and treatment of the rare neurological diseases caused by mutations in the ATP1A3 gene (Alternating Hemiplegia of Childhood – AHC; Rapid Onset Dystonia and Parkinsonism – RDP; CAPOS Syndrome).
The data collected in the Platform will be managed in full compliance with the rules defined in the Charter of the Consortium, based on international ethical standards and national and international regulations on privacy and security. Thanks to the implemented workflow, based on principles and methods of platform cooperativism and patient engagement, the data can thus be collected in the Platform and shared in an ethical and informed way by all actors involved in the biomedical research process (doctors, patients and researchers, scientific and academic institutions).

In particular, the data can be re-used safely and effectively for an indefinite number of studies and projects carried out by the Centers of the IAHCRC Consortium, in collaboration with patient associations and other external, public and private bodies, both internationally and nationally. They can also be made accessible for larger-scale projects, always based on data sharing policies jointly-agreed by the Assembly of the IAHCRC member Centers and the patient representatives of the AHCIA International Alliance.

EXPECTED RESULTS: In the short term, the Platform will serve the data collection for the OBSERV-AHC Study (Prospective Observational Natural History and Therapy Study on AHC), which will be launched in the first trimester 2018 and will last for three years, with the Scientific Coordination of the Neurology Clinic at the Duke University (Durham, NC USA). Moreover, a video library is currently being implemented, jointly accessible by patients, their reference clinicians, and a group of international experts as reviewers, to classify the paroxysmal episodes characteristic of the ATP1A3 diseases and the other movement disorders associated. This video library will be used in particular in the first phase of the OBSERV-AHC Study. Along with the data already produced by previous IAHCRC studies, which will soon be imported into the Platform, with the data produced by the OBSERV-AHC Study and those produced by other IAHCRC studies that will be launched in parallel, a database will be created in the medium and long-term, usable for larger-scale studies on the ATP1A3 diseases: natural history, clinical trials for new candidate compounds, quality of life …..
This database may also be used to develop Guidelines for the Assistance to the Patients, and for other purposes of dissemination and professional and academic training.

PARTNERS: Basic Research and Clinical Centers member of the IAHCRC International Consortium; Patient Associations of the International Alliance AHCIA.

ACTIVITIES AT IEMEST: The IEMEST coordinates the whole project and develops the software application, using the development tool “RedCap© Electronic Data Capture Tool”. The Institute will also provide the hosting and maintenance of the Platform for the next ten years, and will be in charge of the data management, upon appointment of Assembly of the IAHCRC member Centers.


Research project "Experimentation of nanostructured treatments with anti-dust properties"

commissioned by the company DETECO LTD Porcia (PN), , Region Friuli Venezia Giulia LR 3/2015 art. 32, paragraph 1- Contributions in favor of firms belonging to the home appliance sector and its supply chain for industrial research, experimental development and innovation.


Research project "Experimentation of innovative nanomaterials for the sanitization of metal surfaces"

commissioned by the company ECODUE LTD Porcia (PN), Region Friuli Venezia Giulia LR 3/2015 art. 32, paragraph 1- Contributions in favor of firms belonging to the home appliance sector and its supply chain for industrial research, experimental development and innovation.


Research project "Testing of innovative nanostructured coating to increase the duration of molds for thermoplastics"

commissioned by the company DELLEVEDOVE ADELCHI S.N.C. Brugnera (PN), with the collaboration of the Department of Physics, University of Modena, Decr. N. 3521 dd. October 19, 2015, the Region Friuli Venezia Giulia LR 3/2015- Contributions in favor of firms belonging to the home appliance sector and its supply chain for industrial research, experimental development and innovation.


Research project "Testing of innovative conservation treatments based on nanotechnology for the protection of natural stones".

Project funded in collaboration with the Interdisciplinary Dep. "Research Laboratory for Diagnosis of Cultural Heritage" at the University of Bari.


E.U. Projects

Families Live European Week of Sport (FeEL EWoS) 

FUNDER: European Commission, Erasmus+ programme, Action SPORT: Not-for-profit European sport events

AIMS: The main object of the project is the organization of a not-for-profit European sport contest for children (aged 6-14), conducted simultaneously in 6 EU countries (Italy, Portugal, Turkey, Iceland, Croatia, and Spain) during the European Week of Sport (EWoS), 19th-25th September 2016. During the project, 12,000 children will attend seminars related to themes promoted by the EWoS (social inclusion, equal opportunities, health-enhancing physical activity, increase participation in sport, and equal access to sport), and they will perform many different sport activities. During the weekend a “Family sport & recreation festival” will be organized to involve the family members (around 24,000). Moreover, the involvement of a total of 180 volunteers, Ambassadors of Sport, will make it possible to hold the planned activities and will make the concept that exercise is fundamental for a good quality of life more widespread.

EXPECTED RESULTS: The results obtainable from the project will bring a considerable contribution to promote voluntary activities in sport, together with social inclusion, equal opportunities and awareness of the importance of health-enhancing physical activity through increased participation.

PARTNERS: Universities: eCampus University (IT); University of Split (HR).
NGOs: International Sports Studies Association (TR); Krefjandi (IS).
Sport clubs/associations: Club Sport Asociation Servitenis (ES); University Basket Club Albacete´S Campus (ES); Albacete Basketball Schools (ES); Club Athletics Albacete (ES); Swimming club FORCA for persons with disabilities (HR); Athletic club Srce for persons with disabilities (HR); Table tennis club for persons with disabilities "RIJEKA" (HR); Gazi University Foundation Private Schools Association of Youth and Sports Club (TR); Associação de Futebol Amador de Lousada (PT); CRACS - Coletividade Recreativa de Ação Cultural de Sousela sport club (PT); IR Reykjavik Sport Club (IS); ASD Sporting club (IT).
Schools: CEIP San Fulgencio (ES); IES Amparo Sanz (ES); Diocesano School of Albacete (ES); Javier Villalba Garcia School (ES); Public School Of Primary And Infant Of Albacete (ES); Elementary school Srdoči (HR); Elementary school Gornja Vežica (HR); Elementary school Sveti Matej (HR); Feride Bekçioglu Secondary School (TR); Gazi University Foundation Private Secondary School (TR); Agrupamento de Escolas de Dr. Mário Fonseca (PT); Elementary school of Seltjarnarnes (IS); Elementary school of Garðabær (IS).
Public organizations: Municipality of Albacete (ES); Governorship of Ankara (TR); Municipality of Lousada (PT).
Sport federations: Rijeka Sports Association For Persons With Disabilities (HR); Turkish Athletics Federation (TR).

ACTIVITIES AT IEMEST: Head of project. the IEMEST will coordinate the activities in the 6 different countries. Moreover, it will train the Ambassadors of Sport during the international workshop in Palermo.




hidroenergyFUNDER: POR FESR Sicilia 2007-13, Linea di intervento

AIMS: The aim of this project is to plan and set up hydroelectric power plant prototypes based on the recovery of dissipated energy, thus aiding the diffusion of establishments capable of transforming energy from renewable sources into electricity to meet regional energy needs through the optimization of the exploitation of existing alternative energy sources.

EXPECTED RESULTS: Currently a limited number of mini-hydroelectric plants are installed in abstractors for irrigation or drinking , where the excess energy is converted into electricity by the use of hydraulic turbines coupled to electric generators. An alternative to the process of energy dissipation is represented by the transformation of surplus energy into electricity through turbines. HYDROENERGY will be addressed with the realization of an integrated system, which allows the modulation of the pressure in the network through the use of hydraulic turbines, with yields significant in the transformation, by mechanical energy to electrical energy. The results obtainable from the project will bring a considerable contribution to a new model of production of electrical energy. It provides a scheme technologically innovative smart grid to be applied at the local level, able to accommodate and redistribute energy flows coming from hydroelectric production units powered by renewable energy sources. The project partners HYDROENERGY are engaged in designing and construction of hydroelectric prototype based on the recovery of the energy dissipated by the sources of existing production. on the recovery of the energy dissipated by the sources of existing production.

PARTNERS: Onda Energia s.r.l., Italy; Siritec s.r.l., Italy; Proxima s.r.l., Italy; Università di Palermo, Italy.

ACTIVITIES AT IEMEST: As part of the project, the IEMEST has been entrusted with the identification of environmental and infrastructural parameters relevant to the conceptual planning phase, as well as with setting up a Geographic Information System associated with the project.



 Cyber Brain (Pole of Innovation Cyber Brain) 

brain 1FUNDER: PON «Ricerca e Competitività» 2007-2013, Linea di intervento, E.U.

AIMS: The aim of this project is to build a new biotechnological platform, located in the regions of Campania and Sicily, and devoted to neurocybernetics, aimed at designing novel systems that will allow the development of implantable devices and neuroprosthesis for the study of various neurodegenerative diseases.

EXPECTED RESULTS: A structural expansion project is creating an infrastructure of excellence in the South of Italy with the aim also to create new markets that are still unexplored. The infrastructure will develop implantable devices and neuroprosthesis that can capture and transmit neural signals to the study of various neurodegenerative diseases. These activities will be closely related to the study of brain implants with strong scale of miniaturization. Wireless signals will be used for the invasive monitoring of patients with brain pathologies. The structural expansion project is related to a training project which aims at creating qualified personnel specialized in cross-cutting areas of the Polo.

PARTNERS: Fondazione NEUROMED, Italy; Fondazione NEURONE, Italy.

ACTIVITIES AT IEMEST: The IEMEST is establishing a Laboratory of neuroanatomy devoted to test electrocorticographic implantable devices in vivo and to study the effects of these implants, in particular using in vitro and in vivo and post-mortem techniques, as well as in neuronal cultures (including 3D cultures), and the biocompatibility and bioabsorbability of the materials used. The Laboratory of Neuroanatomy will be fitted with advanced research equipments.



 PERIMA (Produzione Eolica con Ridotto Impatto Ambientale) 

PERIMAFUNDER: Linea di intervento del POR FESR Sicilia 2007-2013, E.U.

AIMS: Design and implementation of Eolic plants, which can be raised and lowered easily and with considerable frequency as supporting elements of mini wind turbines, in order to reduce the environmental impact in the area with a tourist destination.

EXPECTED RESULTS: Locating a system of sliding between the lifting elements that ensures the due stiffness of the system during lifting and maximum elevation. Identification and testing of a lifting system that ensures repeatability and reliability in lifting operations.

PARTNERS: Università di Palermo, Italy; Elettrocostruzioni s.r.l., Italy; ONDA s.r.l., Italy; IMAM Ambiente s.r.l., Italy; SIRITEC s.r.l., Italy;

ACTIVITIES AT IEMEST: Analysis of the measured parameters during operation of the prototype, monitoring of industrial testing and research of the optimal changes to be applied to the prototype during the phases of implementation and testing. Basic research on wind in Sicily. Studies and elaborations aimed at fundamental research on the dynamics of the winds in Sicily, with particular reference to their distribution over time, even in the night periods and their variability on the time scale necessary to operate short height variations of the pole. Fundamental research on the problems relating to the lifting of heavy loads, the bending stress of the structural elements joined, to the drilling of foundation with high thixotropy, to the structural stresses and noise produced by two-bladed propeller and a three-bladed and more in general the proper functioning of the prototype.



Others Projects

 3D-CUBRO-SPACE (Three-Dimensional CUlture of BROnchial mucosa in microgravity: a new model to study respiratory cell differentiation and stress during SPACE-flight) 

NASAFUNDER: European Space Agency (ESA) and National Aeronautic and Space Administration (NASA).

AIMS: This project, submitted to the “International Space Life Sciences Research Announcement 2014” (ILSRA-2014) call by ESA, will involve a preliminary on-ground phase carried out by the American partners, during which the samples will be prepared and adapted to the equipment on board the International Space Station (ISS), followed by the experiments in space, after which the samples will be analyzed by the four European research groups to study various cellular and molecular characteristics. The research activities will begin in 2016, and are expected to conclude in 2020.

EXPECTED RESULTS: The project aims to provide a significant and valuable contribution to our knowledge on the effects of the absence of gravity on the respiratory system, and the results will benefit future manned space missions, including those planned for Mars; moreover, the innovative cell culture model can be applied in future studies on the effects of gravity in other anatomical regions.

PARTNERS: the University of Southampton (UK), the Leiden University Medical Centre (The Netherlands), the University of Palermo (Italy), the University of Texas Medical Branch (UTMB) at Galveston (TX, USA), the Wyle Laboratories (FL, USA), and the National Aeronautic and Space Administration (NASA).

ACTIVITIES AT IEMEST: Studying samples once they are sent back to Earth: morphological analyses and experiments on the levels, expression and cellular and subcellular localization of stress proteins.



 DIREF (Citrus tristeza virus and Huanglongbing: Development of techniques for Integrated pest management, Resourceful, Easy to use and Fast) 

DIREFFUNDER: Ministry of Agriculture Food and Forestry, Italy.

AIMS: The aim of the project is to develop innovative diagnostic techniques against the two most dangerous pathogens of citrus , Citrus tristeza virus - CTV and Huanglongbing - HLB. It is very important that the method can be used directly in the nursery or in the field. CTV appears to be present in the Italian regions such as Sicily, Calabria and Apulia since 2002 , while HLB does not appear to be present either in Italy or in Europe. Some experiments will be carried out at the Universitad Politecnica de Valencia because this structure has a laboratory for quarantine plant pathogens . The project will last two years , the operating units involved will work together to develop diagnostic techniques and test them directly in the nursery. Some repellent products will be tested for insect vectors of CTV and HLB .Screenhouse with different types of nets, will be test to identify the best microclimate for citrus trees.

EXPECTED RESULTS: Development of a rapid and sensitive diagnostic technique. We will try to get the result of the analysis within 4 hours with a sensitivity of at least 1000 times higher than a standard DAS-ELISA test. We will try to develop a protocol for more suitable integrated pest control. we will study the biological factor involved in citrus when this plants will be grown under greenhouse.

PARTNERS: Università degli Studi di Catania, Italy; Molecular Dynamics srl, Italy; Vivai Chiarello Fabio, Italy.

ACTIVITIES AT IEMEST: Head of project; The IEMEST will develop the method of diagnosis that will be based on flow-through-hybridization with high thermal differential. We will try to synthesize a poly-probe containing six sections of cDNA that will contain 3 sections of p20 gene of CTV of 3 different biotypes with particular attention to isolated T385 , T36 and SY568 and 3 parts of a gene allotted in HLB that will contain significant differences between the three biotypes related to Candidatus Liberibacter africanus , Candidatus Liberibacter asiaticus and Candidatus Liberibacter americanus.



 CEGEF (Construction of Electricity Generation Energy Facilities) 

CEGEFFUNDER: Serbian Ministry of Energy, Development and Environmental Protection, Serbia

AIMS: Following the public tender notice published by the Serbian Ministry of Energy, Development and Environmental Protection, IEMEST, was awarded for the final design, research, and construction of five hydroelectric plants (4 Mega Watt) in Serbia, in the towns of Tutin and Ivanjica.

EXPECTED RESULTS: Study of innovative solutions for hydro energy production applying electromechanical equipments, with high efficiency. The hydropower plants have the followings characteristics:








138 kW

150 kW

214 kW

2300 kW

260 kW


628 MWh

683 MWh

974 MWh

6058 MWh

1137 MWh


0,124 €/kWh

0,124 €/kWh

0.123 €/kWh

0,099 €/kWh

0,120 €/kWh

PARTNERS: ONDA Energia s.r.l., Italy; Studio Galli Ingegneria s.p.a., Italy.

ACTIVITIES AT IEMEST: Research and Innovation



 NHAM (Novel Heterocyclic Antibacterial Molecules) 

NHAMFUNDERS: IEMEST; Università di Milano Bicocca.

AIMS: The aim of the project is to commercialize novel compounds synthesized by IEMEST researchers with demonstrated "in vitro" antibacterial activity against recently isolated antibiotic susceptible and resistant Gram-positive and Gram-negative bacteria.

EXPECTED RESULTS: Commercialization of: i) a series of linezolid analogues with a specific binding affinity towards the 23S ribosomal region; ii) a series of fluoroquinolones analogues able to inhibit DNA-gyrases and Topoisomerase IV. Moreover, it is expected that, as a positive consequence of molecular design, the new compounds had at least a comparable, if not superior, activity than antibiotics currently in clinical use. The results will offer an alternative solution for the problem of multi-drug-resistance of Gram-positive and Gram-negative pathogens.

PARTNERS: Università di Palermo, Italy; Università di Milano Bicocca, Italy.

ACTIVITIES AT IEMEST: IEMEST contributed in partnership with the University of Milano Bicocca to the intellectual property rights protection of new molecules active against multi-drug resistant bacteria, also financing the registration of two patents currently under evaluation of the Italian and American patent committees. IEMEST is currently working of the commercialization of the patent.



 ELIDI (Epigenetics of Liver Diseases) 

ELIDIFUNDERS: Ministero della Salute; Associazione Italiana per la Ricerca sul Cancro; IEMEST

AIMS: The aim of the project is to develop innovative diagnostic epigenetic markers and murine models of liver diseases. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of specific biomarkers for early diagnosis of HCC represents an active field of research. Increasing evidence indicates that fat accumulation in the liver, defined as hepatosteatosis, is an independent and strong risk factor for developing an HCC. MacroH2A1, a histone protein generally associated with the repressed regions of chromosomes, is involved in hepatic lipid metabolism and is present in two alternative spliced isoforms, macroH2A1.1 and macroH2A1.2. These isoforms have been shown to predict lung and colon cancer recurrence but to our knowledge, their role in fatty-liver associated HCC has not been investigated previously. In this project, we will use immortalized cells, primary hepatocytes, human biopsies and mice models, with genetic, genomic, biochemical and morphological approaches to address this issue.

EXPECTED RESULTS: Development of murine models to study the progression from hepatic steatosis, a simple and harmless accumulation of fat, to inflammatory steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Development of a diagnostic and prognostic histological marker for the above mentioned diseases in patients.

PARTNERS: University College London (UCL), London, UK; IRCCS “Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.

ACTIVITIES AT IEMEST: IEMEST, through its multiple and deep connections with the local infrastructures, University and Hospitals, will provide human samples for the study, as well as, will set up appropriate immunomorphological techniques to determine the hepatic damage.



 SIAHE (Silybin as Hepatoprotectant) 

SIAHEFUNDER: Istituto Biochimico Italiano “Lorenzini"

AIMS: The project aims to evaluate the molecular mechanisms underlying the hepatoprotective effects of silybin. In particular we will assess the effectiveness of such a substance in an in vitro model of hepatic steatosis . For this purpose we will use a continuous cell line culture of hepatocytes ( HepG2 ). The cells will be treated with different concentrations of oleic and palmitic acids ( 0.5-2.5 mM ) in the presence and absence of silybin. The cells will be harvested at different time intervals to assess the effect of silybin on the inflammatory response and oxidative stress . In a second set of experiments we will use the medium obtained from the previous experiment to cultivate hepatic stellate cells , whose activation by hepatocytes is responsible for the evolution of liver steatosis in fibrosis and subsequently cirrhosis. The experiments will be carried out in part at the Laboratory of Advanced Biology , Department of Pharmaceutical Sciences of the University of Catania, where there exist all the tools to carry out the experimental protocols.

EXPECTED RESULTS: Identification of the molecular mechanisms of fat storage inside of the hepatocytes and the molecular mechanisms through which the silybin reduces the storage of fat. In addition, our experiments will allow to identify the main mechanisms of cross-talk between hepatocytes and hepatic stellate cells and as silybin is involved in the process.

PARTNERS: Istituto Biochimico Italiano “Lorenzini”, Italy; Università degli Studi di Catania, Italy.

ACTIVITIES AT IEMEST: Leader and coordinator of the project. The IEMEST will develop treatment protocols to evaluate the in vitro pharmacological and toxicological profile of silybin. The IEMEST will be also involved in the protocols dedicated to imaging, the design of probes for the evaluation of' inflammation and oxidative stress and statistical analysis of all the results obtained.



 RECORDS (Rethinking Cord-based Solutions) 

RECORDSFUNDERS: IEMEST, Italy; Auxocell Laboratories Inc., USA; Stemcell Newtech Scientific, Cyprus.

AIMS: Umbilical cord is an extraembryonic organ essential for fetal life. Its potential uses after birth are studied worldwide for applications in regenerative medicine. Use and banking of hematopoietic precursors derived from umbilical cord blood are an established reality supported by public and family (private) banks. The use of other cells which reside into the organ matrix, which have features of mesenchymal stem cells, may open new paths in cell therapy for numerous non-hematologic diseases Cord cells (which are free from ethical concerns) may be easily obtained after partum, ex-vivo cultured, may be easily differentiated in mature cells belonging to several tissues and organs (as liver, pancreas, lung, bone, cartilage), feature further characteristics, as the low immunogenicity, which may favour their transplantation. In addition, few family banks just offer the possibility to store without manipulations these cells, parallel to cord blood ones, for future autologous uses. The aim of the project is to increase the possibilities of these cells, by studying both isolation and storage protocols which may be compatible with further clinical use of these cells. Moreover we will study new differentiation protocols to use these cells for diseases such as liver fibrosis, diabetes, osteoarticular diseases. In particular, we are working with cells derived from umbilical cords at different gestational ages (also preterm) to set up culturing and differentiation protocols in accordance to GMP procedures. Another aim is the characterization of differentiated cells by using advanced in vivo models. The great potentials of perinatal stem cells need advanced studies to be fully explored, and to rethink the new uses of umbilical cord, which continues sustaining life, even after birth.

EXPECTED RESULTS: Development of innovative in vitro and in vivo model sto study differentiation and cell therapy applications of cord cells. Study of the immunological features of these cells to limit the use of immunosuppressive therapies post-transplantation.


ACTIVITIES AT IEMEST: IEMEST acted first providing a working link between public and private partners, both national and international ones, which in the different phases contribute to achieve project’s goals. In addition, it will offer access to advanced laboratories to perform complex analytical techniques which are needed to a correct a phenotypical evaluation of differentiated cells to meet the safety needs of cell therapy approaches.



 CRiT2DiP (Novel Markers of Cardiovascular Risk in Type II Diabetes Patients) 

CRiT2DiPFUNDERS: NovoNordisk s.p.a., Italy; IEMEST, Italy.

AIMS: The aim of the project is to identify novel markers of cardiovascular risk, particularly in patients with diabetes type-2. Cardiovascular diseases are the leading cause of morbidity and mortality in our country, and therefore early recognition of high-risk individuals may be able to implement appropriate time for the necessary measures to reduce the risk of future events. In fact, cardiovascular events are nothing more than the expression of a process (the atherosclerotic disease) that lasts for years, even decades , and most of the time in an absolutely silent It is therefore of great importance to identify individuals at high cardiovascular risk, in order to anticipate and improve therapeutic intervention for proper prevention. These health issues are particularly important in patients with diabetes type-2. This project evaluates novel and emerging markers of cardiovascular risk for patients with diabetes type-2, for a better management of their disease and to implement better prevention of future complications.

EXPECTED RESULTS: Identification of novel markers of cardiovascular risk, which may contribute to the prevention and clinical management of patients at high cardiovascular risk, such as those with type-2 diabetes.

PARTNERS: University of South Carolina, USA; University College of London, U.K.

ACTIVITIES AT IEMEST: The IEMEST, through its multiple and deep connections with the local infrastructures, Universities and Hospitals, will provide human samples for the study, as well as, will set up appropriate biochemical procedures.





Job opportunities





September 2018

The I.E.Me.S.T. Institute Invites you to participate on Tuesday, October 30, 2018, at 15.30, at the Institute's headquarters (via Michele Miraglia, 20 Palermo) at the press conference to present the IAHCRC-CLOUD Platform project, a project aimed at creating an international platform of collection and sharing of data at the service of the collaborative studies of the IAHCRC Consortium.



July 2018

Bando Borsa di Studio IEMEST 2018 - Sperimentazione di malte innovative ad alta efficienza energetica con proprietà fotocatalitiche

qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.



July 2018

Bando Borsa di Studio IEMEST 2018 - Sperimentazione di malte innovative ad alta efficienza energetica, disinquinanti per bioedilizia e beni culturali

qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.


July 2018

Bando Borsa di Studio IEMEST 2018 Sviluppo e sperimentazione di malte innovative geopolimeriche_1

qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.



July 2018

Bando Borsa di Studio IEMEST 2018 Sviluppo e sperimentazione di malte innovative geopolimeriche_2

qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.



"Exploring a novel Approach to COPD Treatment: the effect of anti IL-5 receptor (benralizumab) in an ex vivo 3-D model(ExACTstudy)"

qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.




Progetto VACure
"Terapia a Pressione negativa per la cura delle ulcere del piede diabetico"

per saperne di più...



30 january 2018

miRNA expression profile of retinal pigment epithelial cells under oxidative stress conditions: a study from the Antonella Sidoti’s group.. per saperne di più...



16 november

International Conference “Green Conservation of Cultural Heritage”
I.E.Me.S.T. Invites the participation of the International Conference “Green Conservation of Cultural Heritage”
read more here...



19 october

Meeting "Materiali innovativi a basso spessore per l'efficientamento enegetico dell'architettura moderna e storica"
Lo I.E.Me.S.T. Invites the participation of the meeting at h.14:00 - to aula magna of DARCH, ed.14 viale delle scienze - Palermo



29 september

The Qanat Publishing House and the Institute I.E.Me.S.T. They invite you to the book's presentation Francesco di Franco L'isola che amo
5:30 pm - 7:00 pm, at IEMEST, in Via Michele Miraglia, n.20 - 90139 Palermo



12 july

Insieme per le malattie genetiche rare
"TMAU.. contro il disagio, la solitudine e l'emarginazione dei più piccoli..."
Università degli Studi di Messina - Dip. di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali - Lab. di Genetica Molecolare



15 june

Progetto P.I.P.A.C. “Nuovi Percorsi Integrati per il paziente con Psoriasi/Artrite psoriasica e Comorbidità - Valutazione dell’indice di gradimento"



12 june


- Domanda di partecipazione



9 may

Siamo lieti di invitarVi al FERNANDEZ OPEN STUDIO, un evento promosso da YO.CO.CU. nell'ambito della manifestazione Settimana delle Culture 2017 in collaborazione con la Soprintendenza Archivistica della Sicilia e Archivio di Stato di Palermo, con il Patrocinio dell'Ordine degli Architetti della Provincia di Palermo, dell'Istituto Euro-Mediterraneo di Scienza e Tecnologia I.E.ME.S.T. e dell'Accademia di Belle Arti Kandinskij di Trapani. read more here...



2 may

NanoWorld Conference 2017 in Boston: award to a I.E.ME.S.T. Researcher on the theme of the contribution of nanotechnologies to the sustainability of Architecture. read more here...



28 april

Progetto P.I.P.A.C. “Nuovi Percorsi Integrati per il paziente con Psoriasi/Artrite psoriasica e Comorbidità - Valutazione dell’indice di gradimento"



16 march

The Euro-Mediterranean Institute of Science and Technology (IEMEST) reaches new heights:



1 march

Researchers of the Italian National Research Council (CNR) and of the Euro-Mediterranean Institute of Science and Technology (I.E.ME.S.T.) have published a new research on the “Journal of Proteome Research”, about the early mechanisms of Alzheimer’s disease (AD). read more here...



9 february

Bando di Concorso per titoli per il conferimento di un premio di Ricerca per Giovani Ricercatori dal Titolo: "Sperimentazione di trattamenti conservativi innovativi basati su nanotecnologie per la protezione di materiali lapidei naturali" read more here...



30 november

An international team of scientists including University of Palermo and IEMEST researchers and colleagues from Poland (Medical University of Gdansk) and U.S.A. (University of Maryland) demonstrated a new action mechanism of the drug doxorubicin in vitro. read more here...



27 september

Research anticancer: Palermo researchers involved in the discovery of a chemotherapy that blocks the cancer cells.
In a study recently published in the international journal "Epigenetics", researchers from the Euro-Mediterranean Science and Technology (Manlio Vinciguerra, Francesca Rappa and Francesco Cappello), in collaboration with Italian English, Spanish, Estonian, Czech and US scientists, have demonstrated the effects and efficacy of guadecitabine, a chemotherapic agent, useful in preventing the progression of HCC, both in vitro through the use of cell models and in vivo through the use of murine models. The study was coordinated by Manlio Vinciguerra while Francesca Rappa and Francesco Cappello conducted experiments and morphological evaluations. read more here...



05 september

Editorial Results for IEMEST Researchers
Antonio Palumbo Piccionello and Francesco Cappello acted as Guest Editors for Current Pharmaceutical Design, an international journal edited by Bentham Science, with an hot topic issue on current and perspective therapies for Alzheimer’s disease. read more here...



28 july




13 july

Sicilia-California: allo Iemest di Palermo partono gli incontri bilaterali di scambio
Incontri d’affari, workshop, incontri bilaterali mirati a obiettivi di cooperazione e promozione del territorio siciliano sia sul piano delle risorse scientifiche che sul piano dello sviluppo delle imprese. Questi gli obiettivi principali della giornata Sicilia-California organizzata, la mattina di mercoledì 13 luglio 2016, alle ore 11,00, presso lo Iemest di Palermo (via Michele Miraglia, 20). read more here...



18 May

Dal 18 maggio 2016 l’Istituto Euro-Mediterraneo di Scienza e Tecnologia (I.E.ME.S.T.), presieduto dal Prof. Bartolomeo Sammartino, ospiterà per due settimane un gruppo di studenti di Medicina della prestigiosa Università americana di Houston (UH) in Texas. read more here...



14 April

The project submitted by a group of researchers at IEMEST
(PI: Filippo Macaluso; others: Kathy Myburgh, Valentina Di Felice, Fedele Termini, Antonella Marino Gammazza, Claudia Campanella, Rosario Barone, and Maura Marino Gammazza) has been selected in the call Erasmus+ SPORT - Not-For-Profit European Sport Events. read more here...



3 February

A research study on skeletal muscle published in Nature "Scientific Reports".
The results of a study, funded by PRIN, on molecular anatomy of skeletal muscle have been published in the journal "Scientific Reports" (from the publishers of "Nature"). The research has been conducted by a research group of our Institute coordinated by Valentina Di Felice (first name: Rosario Barone) with the participation of research group of Prof. Sergio Adamo, University of Rome "La Sapienza". read more here...



18 January

A new mechanism to fight liver cancer showed by IEMEST’s researchers.
An international team of scientists including IEMEST researchers and colleagues from U.K. (University College of London, Queen Mary University of London e Nottingham Trent University), The Netherlands (University Medical Center of Groningen), Estonia (Tallin University of Technology), Australia (University of Sidney) and Spain (Campus Can Ruti), showed for the first time a mechanism by which the hepatocellular carcinoma, one of the most aggressive liver cancer, is able to resist to chemotherapy. read more here...



30 december

A group of IEMEST researchers, lead by Dr. Claudia Campanella, Head of the Section of studies on micro- and nano-vesicles as biomarkers, has showed for the first time one the mechnisms of action of a known chemotherapics, the SAHA (suberoylanilide hydroxamic acid). This mechanism involves the nitration of the mitochondrial protein HSP60. The latter, after nitration, is released from tumor cells by exosomes. HSP60 commonly protects tumor cells from stress. Its secretion through exosomes favours tumor cell death as well as activates an antitumor immune response. This paper has been published this month on ONCOTARGET (Impact factor: 6,359):



12 november

On November 13th and 14th, during the conference “Science in Ancient / Science for Ancient. From scientific knowledge in the Hellenistic age to the virtual archeology” organized by the “Regione Siciliana”, the IEMEST researcher Francesco Di Paola will give a Lecture on “The Morgantina Silver Archaeological Treasure at the Museum of Aidone” with other colleagues in the field of Computer more here...




4 november

The IEMEST's Researchers Filippo Macaluso, Kathy Myburgh and Giosuè Lo Bosco won the second call for innovative apps in the environmental and social domains, MYGEOSS project.
Our researchers proposed the "eQUOS" app (Environment Quality for Outdoor Sports): by using an open database tracking the changing environment, eQUOS will suggest to the final user whether to perform a specific outdoor physical activity in a specific geographical area on the basis of the environment quality, i.e. climate, water, coastal areas, and atmospheric composition. For further information, please visit:



30 september

The Director of the Institute in the list of the Top Italian Scientists.
Prof. Francesco Cappello, Director of our Institute, has been included in the ranks of the Top Italian Scientists elaborated by VIA-Academy. This ranking includes Italian scientists of all disciplines (science and humanities) operating in Italy and in the world. The ranking is compiled based on h-index, the index that measures the number of international publications, and their impact on the international scientific community assessed on the number of citations received. For further information, please visit:



29 july

A Potential Link between lipoproteins and asthma: a IEMEST's study
A recent study carried out by two research groups coordinated by Prof. Scichilone and Prof. Rizzo, IEMEST researchers, demonstrated for the first time that, in asthmatics, the least pro-inflammatory lipoproteins (LDL-1 e LDL-2) are reduced, and the pro-inflammatory (LDL-3 and LDL-4) elevated compared to healthy controls. In addition, in asthmatics the serum concentrations of LDL-1 are positively associated with lung function, whereas the pro-inflammatory LDL-3 are inversely correlated with lung function. These findings suggest that the LDL are implicated in the pathogenesis of asthma, in that, they may act by igniting the inflammatory cascade of the airways.



13 july

A new study correlates obesity associated with insulin resistance to Alzheimer's disease
Two researchers of our Institute are co-authors of a study carried out along with researchers of the C.N.R. of Palermo, which correlates the insulin resistance, that develops in some obese individuals, with the development of Alzheimer's disease. The study has been published on "Current Alzheimer Research". In particular, insulin resistance determines, among other damages, oxidative stress and mitochondrial dysfunction in neurons of the mice subjected to a high fat diet, and this leads to early damages that are pathognomonic for Alzheimer's disease. Treatment of metabolic disorders, then, can prevent the development of this serious neurodegenerative disease in this subpopulation of subjects. Part of this work was carried out by using the equipment of the Laboratory of Neuroanatomy funded by PON 'Research and Competitiveness' 2007-2013, measure
Link to the paper: here



06 july

A novel biomarker for the colo-rectal cancer
A group of IEMEST’s researchers, coordinated by prof. Francesco Cappello, published a paper in the journal "CANCER" (the official journal of the American Cancer Society) on a new marker for the diagnosis and the follow-up of patients with colorectal carcinoma. In this work it has been shown that a stress protein (Hsp60) bound to exosomes (vesicles secreted by tumor cells) is present in very high levels in patients who undergo surgery while its levels are reduced drastically one week after the surgery. These results make exosomal Hsp60 a putative tool for the diagnosis and the follow-up of this cancer. The work was conducted in collaboration with researchers of the University of Palermo, the National Institute of Health in Rome and the University of Maryland at Baltimore, USA.
The paper can be read on-line: here.



03 june

At the Euro-Mediterranean Institute of Science and Technology has been established an international research center devoted to the study of the chaperonopathies of the nervous system.
The Chaperoning System participates extensively in the development, functioning, protection, and repair of the nervous system from conception to old age. Read more here.




25 may

Giuseppe Venturella invited speaker at a congress on wild cherry.
Prof. Giuseppe Venturella, full professor of Forest Botany and Mycology and Leader of the "Environmental Botany and Mycology applied to agro-forest ecosystems" Section of IEMEST has been invited to give a talk titled "Botanical, ecological and distributive features of wild cherry" at the 46° Festival of Cherries that will be held on June 13th 2015 at Chiusa Sclafani (Palermo).




21 may

A young IEMEST’s researcher awarded for research on diabetes and hepatic diseases.
Dr. Angelo Maria Patti, member of the Section of Atherosclerosis, Diabetes and Cardiovascular Prevention headed by Prof. Manfred Rizzo, is among the four winners of the 1st scholarship in memory of Carmelo Schembari. Dr. Patti has been awarded for his research on metabolic effects of nutraceuticals in patients with diabetes mellitus type 2 and hepatic steatosis.



20 may

An authoritative "Position Paper" on physiological functions of extracellular vesicle.
Francesco Cappello, member of the Management Committee of the COST action-ME-HAD, is one of the authors of the important work on the physiological role of microvesicles and on exosomes. The focus on this topic is growing after the discovery that these vesicles can be taken from all human biological fluids (such as blood, urine, saliva, etc.) and can be used not only as diagnostic and prognostic markers but also as therapeutic tools of various human diseases, such as cancer, cardiovascular diseases and chronic inflammatory conditions. This study, published in the Journal of Extracellular Vesicles, can be read online here.



19 may

A hormone as a potential anticancer agent.
Two IEMEST’s researchers, Antonella Marino Gammazza and Francesco Cappello, have taken part to a study with colleagues of the Universities of Gdansk and Rzeszow, Poland, which has shown anti-tumor activity of 2-Methoxyestradiol, a physiological metabolite of estradiol, an estrogen hormone produced by the ovaries. This hormone showed to be able in arresting the cell cycle of cancer cells and inducing programmed cell death (apoptosis). This study has been published in the prestigious journal “Oncotarget”.The work can be read online here.



18 may

IEMEST’s researchers published a study of the alteration of glucose metabolism.
The research has been published in the Journal of Cell Physiology and highlighted the effects of the "glucagon-like peptide 2" (GLP-2) on the metabolism of mice treated with a high fat diet. GLP-2 acts as a protective factor against the alteration of glucose metabolism. The work can be read online here. Francesca Rappa and Francesco Cappello have taken part to this work.



A researcher at the Institute for Euro-Mediterranean Science and Technology in the Top Italian Scientist Prof. Manfredi Rizzo, Director of the Department of Population Health, Nutraceuticals And more




Prof. Francesco Cappello will attend as Invited Speaker at the "Experimental Biology 2015" meeting (Boston, March 27st - April 1st) giving a talk titled "Role of chaperones in healthy bowel and IBD"






PROGETTO CYBER BRAIN: PRIMA PUBBLICAZIONE SU RIVISTA “NATURE” The results of a study carried out by the Department of Medicine and Neuroscience of the Euro-Mediterranean Institute of Science and Technology (IEMEST) has been published on March 24th in an international journal, part of the Nature publishing group, called "Scientific Reports". Dr. Antonella Marino Gammazza, the principal investigator of the study, more


Francesco Cappello, Director of the IEMEST, received the appointment as Adjunct Associate Professor at Temple University College of Science and Technology, Department of Biology, Philadelphia, USA. The recognition will lead to the development of new forms of collaboration between the two institutions in the field of biomedicine.



A researcher at the Institute for Euro-Mediterranean Science and Technology in the Top Italian Scientist Prof. Giovanni Li Volti, Director of the Department of Stress Biology, Epigenetics, Sport and more



1st Edition of the Master INNOVA - SEAV Training
video link




Second Galveston-Palermo Meeting



Life Safety and Security (LiSS), the IEMEST's new open access Scientific Journal, has been introduced by Going International in the section "Special of the month".
Read the article at:










The recent paper from Prof. A.J.L. Macario's group: “Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in cancer: Potential Benefits and Risks” published in “Curr Pharm Design" (2013 Jan;19:452-457) has been selected to be featured in World Biomedical Frontiers [ISSN: 2328-0166] because of its innovation and potential for significant impact. World Biomedical Frontiers is a platform that focuses on cutting-edge biomedical research from around the globe and publishes each month papers with significant potential to improve health, or to treat or prevent disease.




Following the public tender notice published by the Serbian Ministry of Energy, Development and Environmental Protection, IEMEST, in Joint Venture with Onda Energia and SGI Studio Galli Ingegneria, was awarded for the design, research, and construction of five hydroelectric plants (4 Mega Watt) in Serbia, in the towns of Tutin and Ivanjica.
On 22nd and 23rd July, the Leader of the group, jointly with the Minister Ms. Zorana Mihajlović, signed the Memorandum of Understanding (MoU), which was the the first important step of the project.
For more info visit:


Importante studio sulla correlazione tra invecchiamento e malattie epatiche

Il processo dell’invecchiamento predispone a disfunzioni epatiche. Comprendere come l’invecchiamento influenza la patologia molecolare delle malattie epatiche è di fondamentale importanza. Nella review “Liver disease and aging: friends or foes?” pubblicata sul prestigioso giornale Aging Cell, il nostro ricercatore IEMEST Dr. Manlio Vinciguerra, ricercatore anche presso l’University College London, discute le cause del fatto sorprendente che comuni malattie epatiche come la steatosi non alcolica, la steatoepatite non alcolica, la cirrosi e l’epatocarcinoma compaiono con una frequenza inferiore negli individui con più di 70 anni.

Ref: Sheedfar F, Di Biase S, Koonen D, Vinciguerra M. Liver diseases and aging: friends or foes? Aging Cell. 2013 Jul 1. doi: 10.1111/acel.12128. [Epub ahead of print]





Bando per la selezione di idee e progetti innovativi



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Lo IEMEST organizza il corso di I livello di GIS che offre ai suoi iscritti la possibilità di migliorare le competenze di giovani laureati, professionisti e impiegati della pubblica amministrazione circa l'uso delle nuove tecnologie applicate alla gestione dell'informazione geografica digitale in ambiente GIS (Geographical Information System) per la pianificazione del territorio e dell'ambiente.

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IEMEST: A new vision and platform to enhance the progress of research and dissemination of knowledge in natural and social sciences

Published by: Going International Information Services




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