The I.E.Me.S.T. Institute Invites you to participate on Tuesday, October 30, 2018, at 15.30, at the Institute's headquarters (via Michele Miraglia, 20 Palermo) at the press conference to present the IAHCRC-CLOUD Platform project, a project aimed at creating an international platform of collection and sharing of data at the service of the collaborative studies of the IAHCRC Consortium.
Bando Borsa di Studio IEMEST 2018 - Sperimentazione di malte innovative ad alta efficienza energetica con proprietà fotocatalitiche
qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.
Bando Borsa di Studio IEMEST 2018 - Sperimentazione di malte innovative ad alta efficienza energetica, disinquinanti per bioedilizia e beni culturali
qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.
BANDO DI CONCORSO PER TITOLI PER IL CONFERIMENTO DI UNA BORSA DI STUDIO PER GIOVANI RICERCATORI DAL TITOLO:
"Exploring a novel Approach to COPD Treatment: the effect of anti IL-5 receptor (benralizumab) in an ex vivo 3-D model(ExACTstudy)"
L'Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST) promuove e favorisce attivamente lo svolgimento di attività di ricerca su argomenti di biomedicina, in particolar modo sullo studio di nuove molecole farmacologicamente attive.
Per questo motivo, l'Istituto, nell'ambito delle proprie attività statutarie, bandisce un concorso per il conferimento di una borsa di studio a favore di un/a giovane ricercatore/trice, spiccatamente capace, di età inferiore a 35 anni alla data della pubblicazione del bando, in possesso di Laurea magistrale in Biologia (o equipollente) con conoscenze maturate su argomenti legati alle colture tridimensionali di mucosa respiratoria. Il vincitore della borsa sarà valutato dal Consiglio Direttivo dell'Istituto per la sua affiliazione in seno all'Istituto e la partecipazione ad attività di ricerca correlate.
qui per scaricare la Documentazione del Bando e la domanda di Partecipazione.
EXTENSION OF THE DEADLINE - 15 march
"Terapia a Pressione negativa per la cura delle ulcere del piede diabetico"
L'Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST) con il presente avviso intende procedere alla ricerca di sponsor per finanziare il progetto VACure "Terapia a Pressione negativa per la cura delle ulcere del piede diabetico" i cui dettagli sono descritti negli allegati: qui per scaricare la documentazione...
miRNA expression profile of retinal pigment epithelial cells under oxidative stress conditions: a study from the Antonella Sidoti’s group.
Deep analysis of regulative mechanisms of transcription and translation in eukaryotes could improve knowledge of many genetic pathologies such as Retinitis pigmentosa (RP). New layers of complexity are daily discovered, such as the preponderant role in regulative functions of miRNAs. We compared changes in the expression of miRNAs obtained from whole transcriptome analyses, between two groups of retinal pigment epithelium (RPE) cells, one untreated and the other exposed to the oxidant agent oxidized low-density lipoprotein (oxLDL), examining four time points (1, 2, 4 and 6 h). We found that 23 miRNAs exhibited altered expression in the treated samples, targeting genes involved in several biochemical pathways, many of them associated to RP for the first time, such as those mediated by insulin receptor signaling and son of sevenless. Moreover, five RP causative genes (KLHL7, RDH11, CERKL, AIPL1 and USH1G) emerged as already validated targets of five altered miRNAs (hsa-miR-1307, hsa-miR-3064, hsa-miR-4709, hsa-miR-3615 and hsa-miR-637), suggesting a tight connection between induced oxidative stress and RP development and progression. This miRNA expression analysis has discovered new regulative functions of miRNAs in RP that should lead to the discovery of new ways to regulate the etiopathogenesis of RP. Here the link of the paper:
International Conference “Green Conservation of Cultural Heritage”
I.E.Me.S.T. Invites the participation of the International Conference “Green Conservation of Cultural Heritage”
The objective of the Conference is to promote greater awareness of the ecological, economic and social aspects of sustainable conservation. In addition to a specific Living Lab activity, that will be held on November 16th at the laboratories of I.E.ME.S.T., during which new materials and innovative technologies will be presented, the conference will be an opportunity to a valid exchange of knowledge on the topics proposed for thematic sessions:
- Biotechnologies and bio-based products;
- Nanomaterials for eco-friendly conservation;
- Feasibility of innovative methods and products;
- Green applications in the conservation practice: successful and unsuccessful case studies;
- Sustainable conservation.
The official language of the Conference is English.
I.E.ME.S.T. with the aim of supporting young talents in the research world, sponsors the Young Researcher Award, a euro 500,00 grant to the most innovative research in the field of sustainable conservation of cultural heritage.
The invited speakers of the Conference are Prof. Maria Jesus Mosquera University of Cadiz (Spain), Prof. Maria Stefanidou Aristotle University of Thessaloniki (Greece), Prof. Robert Pullar University of Aveiro (Portugal), Prof. Rodorico Giorgi University of Florence (Italy).
Among the participants are representatives of prestigious national and international institutes and Universities of about 16 different countries.
For more information visit the website of the event www.greenconservationconference.com
at IEMEST, in Via Michele Miraglia, n.20 - 90139 Palermo
Meeting "Materiali innovativi a basso spessore per l'efficientamento enegetico dell'architettura moderna e storica"
The I.E.Me.S.T. Invites the participation of the meeting at h.14:00 - to aula magna of DARCH, ed.14 viale delle scienze - Palermo
The Qanat Publishing House and the Institute I.E.Me.S.T. They invite you to the book's presentation Francesco di Franco L'isola che amo
5:30 pm - 7:00 pm, at IEMEST, in Via Michele Miraglia, n.20 - 90139 Palermo
Insieme per le malattie genetiche rare
"TMAU.. contro il disagio, la solitudine e l'emarginazione dei più piccoli..."
Università degli Studi di Messina - Dip. di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali - Lab. di Genetica Molecolare
PROROGA DEL TERMINE DI SCADENZA (14/07/2017) - AVVISO PUBBLICO PER LA RICERCA DI SPONSOR PER UN PROGETTO DI RICERCA
Progetto P.I.P.A.C. “Nuovi Percorsi Integrati per il paziente con Psoriasi/Artrite psoriasica e Comorbidità - Valutazione dell’indice di gradimento"
BANDO DI CONCORSO PER TITOLI PER IL CONFERIMENTO DI UNA BORSA DI STUDIO PER GIOVANI RICERCATORI DAL TITOLO: "SPERIMENTAZIONE DI TRATTAMENTI ANTIBATTERICI SU SUBSTRATI METALLICI”
- Domanda di partecipazione
Siamo lieti di invitarVi al FERNANDEZ OPEN STUDIO, un evento promosso da YO.CO.CU. nell'ambito della manifestazione Settimana delle Culture 2017 in collaborazione con la Soprintendenza Archivistica della Sicilia e Archivio di Stato di Palermo, con il Patrocinio dell'Ordine degli Architetti della Provincia di Palermo, dell'Istituto Euro-Mediterraneo di Scienza e Tecnologia I.E.ME.S.T. e dell'Accademia di Belle Arti Kandinskij di Trapani.
Durante l'Open Studio si potrà visitare l'Archivio Professionale dell'Ing. Giorgio Fernandez, vincolato recentemente dal MiBACT, ancora oggi custodito nello studio originale all’interno dell’edificio da lui stesso progettato e realizzato nel 1962. L'Archivio conserva la documentazione completa dei progetti a firma dell'Ingegnere in un arco temporale compreso tra il 1942 e il 2009.
In occasione di tale evento si potranno osservare alcuni degli elaborati grafici originali, lucidi, acquerelli etc., nonché gli strumenti e i tavoli da disegno del tempo.
La visita è un viaggio nel progetto di architettura: dalla genesi dell’idea con gli schizzi preparatori, alla definizione degli esecutivi con dettagli al vero.
L’Ingegnere Fernandez, classe 1920, sarà presente per illustrare i suoi lavori.
NanoWorld Conference 2017 in Boston: award to a I.E.ME.S.T. Researcher on the theme of the contribution of nanotechnologies to the sustainability of Architecture.
Dr. Federica Fernandez, Director of the Interdepartmental Center "Nanotechnologies and Innovative Materials for Health, Architecture and Cultural Heritage" of the Euro-Mediterranean Institute of Science and Technology was invited to the NanoWord Conference NWC 2017 Held on April 3 to 5 in Boston as chairman of the session: Nanotechnology and Nanosciences – Applications and Social Aspects. The NanoWolrd Conference is the world's most important nanoscience and nanotechnology event, in which scientists from the five continents have had the opportunity to confront each other and to present the advancement of their researches to companies and producers on the various industrial applications of nanotechnologies.
The primary goal of NWC is to present state-of-the-art research, recent achievements and global trends in nanoscience and nanotechnology, also promoting cross-disciplinary interactions that can spur the development of this exciting research field. Special emphasis was placed on energy materials and applications, nano-biotechnology, health and environmental safety of nanomaterials and specific techniques to develop nano-devices.
Dr. Federica Fernandez received a special mention for her presentation titled "Nanomaterials for Sustainable Architecture and Conservation of Cultural Heritage: State of Art and Perspectives", with a remarkable success for the interdisciplinarity and the relevance of the topics discussed.
AVVISO PUBBLICO PER LA RICERCA DI SPONSOR PER UN PROGETTO DI RICERCA
Progetto P.I.P.A.C. “Nuovi Percorsi Integrati per il paziente con Psoriasi/Artrite psoriasica e Comorbidità - Valutazione dell’indice di gradimento"
The Euro-Mediterranean Institute of Science and Technology (IEMEST) reaches new heights:
Researchers of the Italian National Research Council (CNR) and of the Euro-Mediterranean Institute of Science and Technology (I.E.ME.S.T.) have published a new research on the “Journal of Proteome Research”, about the early mechanisms of Alzheimer’s disease (AD). In particular, a neuronal cell model was treated with the Aβ peptide, one of the principal agent in AD, to understand which biological mechanisms are modulated in the early stage of the disease. Dr Luigi Inguglia, a researcher affiliated to the I.E.ME.S.T., has used a bioinformatic approach to analyze the mass spectrometry data, from the treated and untreated cells, describing the down-regulation of important factors of the ribosome biogenesis and of the splicing processes. These data, confirmed by immunoblotting assays, show that the dysregulation of the RNA metabolism mechanisms and of the spliceosome components represent a key early event in the Alzheimer’s disease.
Bando di Concorso per titoli per il conferimento di un premio di Ricerca per Giovani Ricercatori dal Titolo: "Sperimentazione di trattamenti conservativi innovativi basati su nanotecnologie per la protezione di materiali lapidei naturali"
- Domanda di partecipazione
An international team of scientists including University of Palermo and IEMEST researchers and colleagues from Poland (Medical University of Gdansk) and U.S.A. (University of Maryland) demonstrated a new action mechanism of the drug doxorubicin in vitro. This mechanism involves the induction of replicative senescence through treatment with low doxorubicin doses inducing HSP60 acetylation. In the lung cancer cell line studied, Hsp60 forms a complex with the onco-suppressor protein p53 favoring tumor progression. Hsp60 acetylation interferes with the formation of the Hsp60/p53 complex promoting its dissociation, causing an increase in the levels of free p53, which can then activate the p53-dependent pathway toward cell senescence. The work was published this month in the journal Cancer Letters (Impact Factor: 5,992) and can be downloaded from the site http://www.sciencedirect.com/science/article/pii/S0304383516306760
Research anticancer: Palermo researchers involved in the discovery of a chemotherapy that blocks the cancer cells.
In a study recently published in the international journal "Epigenetics", researchers from the Euro-Mediterranean Science and Technology (Manlio Vinciguerra, Francesca Rappa and Francesco Cappello), in collaboration with Italian English, Spanish, Estonian, Czech and US scientists, have demonstrated the effects and efficacy of guadecitabine, a chemotherapic agent, useful in preventing the progression of HCC, both in vitro through the use of cell models and in vivo through the use of murine models. The study was coordinated by Manlio Vinciguerra while Francesca Rappa and Francesco Cappello conducted experiments and morphological evaluations.
Hepatocellular carcinoma is linked to epigenetic alterations such as overexpression of variants of histone proteins and hypermethylation of the promoters of some tumor suppressor genes: all these alterations are currently target by the research for new chemotherapeutic drugs.
The chemotherapeutic drug studied in this scientific work is a second generation hypomethylating agent and is able to block the growth of cancer cells.
One of the most interesting aspects of the work is that the guadecitabine has also shown effective on the hepatocellular carcinoma cell models that have an overexpression of the histone variant macroH2A and are resistant to first-generation hypomethylating agents.
The paper is available at this link: http://www.tandfonline.com
Editorial Results for IEMEST Researchers
Antonio Palumbo Piccionello and Francesco Cappello acted as Guest Editors for Current Pharmaceutical Design, an international journal edited by Bentham Science, with an hot topic issue on current and perspective therapies for Alzheimer’s disease. Link: http://benthamscience.com/journals/current-pharmaceutical-design/volume/22/issue/26/
Sicilia-California: allo Iemest di Palermo partono gli incontri bilaterali di scambio
Incontri d’affari, workshop, incontri bilaterali mirati a obiettivi di cooperazione e promozione del territorio siciliano sia sul piano delle risorse scientifiche che sul piano dello sviluppo delle imprese. Questi gli obiettivi principali della giornata Sicilia-California organizzata, la mattina di mercoledì 13 luglio 2016, alle ore 11,00, presso lo Iemest di Palermo (via Michele Miraglia, 20).
L’evento, promosso dal direttore dello Iemest Francesco Cappello e dal comandante Vincenzo Arcobelli (membro del Consiglio generale per gli italiani all'estero in USA e presidente emerito del CSNA USA), rappresenta il primo di un ciclo di appuntamenti che sono stati programmati per presentare agli investitori e al mondo accademico universitario californiano la comunità scientifica e le imprese siciliane per valutare le opportunità di collaborazione e di innovazione attraverso lo scambio del patrimonio di competenze, tecnologie, prodotti e servizi.
Dal 18 maggio 2016 l’Istituto Euro-Mediterraneo di Scienza e Tecnologia (I.E.ME.S.T.), presieduto dal Prof. Bartolomeo Sammartino, ospiterà per due settimane un gruppo di studenti di Medicina della prestigiosa Università americana di Houston (UH) in Texas.
L’evento vedrà impegnati i giovani stagisti statunitensi, sotto la guida del Direttore del Dipartimento di Scienze Umane e Sociali, Turismo, Ambiente e Patrimonio Culturale Dr. Fedele Termini, nella sperimentazione di una metodologia innovativa per la prevenzione e la cura del Disturbo Post-Traumatico da Stress, nell’ambito di un progetto internazionale che vede la partecipazione di alcuni importanti esperti internazionali nel campo tra cui Il Prof. Carl Lindahl, University of Houston, USA, la Prof. Laura Stark, University of Jyväskylä, Finlandia, la Prof. Coppelie Cocq, HUMlab Umeå University, Svezia, e la Prof. Licia Masoni dell’Università di Bologna.
The project submitted by a group of researchers at IEMEST
(PI: Filippo Macaluso; others: Kathy Myburgh, Valentina Di Felice, Fedele Termini, Antonella Marino Gammazza, Claudia Campanella, Rosario Barone, and Maura Marino Gammazza) has been selected in the call Erasmus+ SPORT - Not-For-Profit European Sport Events. The funded project “Families Live European Week of Sport” (FeEL EWoS) is a not-for-profit European sport contest for children (aged 6-14), conducted simultaneously in 6 EU countries (Italy, Portugal, Turkey, Iceland, Croatia, and Spain) during the European Week of Sport (EWoS) (19th-25th September 2016). During the project, 12,000 children will attend seminars related to themes promoted by the EWoS, and they will perform many different sport activities. For further information, please visit:https://eacea.ec.europa.eu/erasmus-plus
A research study on skeletal muscle published in Nature "Scientific Reports".
The results of a study, funded by PRIN, on molecular anatomy of skeletal muscle have been published in the journal "Scientific Reports" (from the publishers of "Nature"). The research has been conducted by a research group of our Institute coordinated by Valentina Di Felice (first name: Rosario Barone) with the participation of research group of Prof. Sergio Adamo, University of Rome "La Sapienza". In particular, the research have revealed for the first time the role of the protein Hsp60 not only in the mitochondrial biogenesis but also in the cross-talk between the muscle cells mediated by exosomes. Part of this work has been carried out in the new IEMEST’s laboratories realised by EU funds (PONa3_00210). These results open new scenarios in the treatment of certain muscle diseases, such as sarcopenia and cachexia. The full article can be found here: http://www.nature.com/articles/srep19781.
A new mechanism to fight liver cancer showed by IEMEST’s researchers.
An international team of scientists including IEMEST researchers and colleagues from U.K. (University College of London, Queen Mary University of London e Nottingham Trent University), The Netherlands (University Medical Center of Groningen), Estonia (Tallin University of Technology), Australia (University of Sidney) and Spain (Campus Can Ruti), showed for the first time a mechanism by which the hepatocellular carcinoma, one of the most aggressive liver cancer, is able to resist to chemotherapy. This mechanism involves the histone protein macroH2A1. The latter is now proposed as a novel target for the therapy of this tumor - very frequent in the Western Countries – which onset is associated to some infections, alcohol abuse, metabolic diseases and pollutants. Our group, formed by Francesca Rappa, Francesco Cappello and Manlio Vinciguerra (the latter is the Corresponding Author of the paper) performed a number of experiments including those to establish, morphologically, the hepatic damages, the subcellular localization of the histone proteins and their levels in the different experimental models that have been used in this study. Cancer Research (I.F.: 9,329) is the most frequently cited cancer journal in the world. The article is available here: http://cancerres.aacrjournals.org/content/early/2016/01/14/0008-5472.CAN-15-1336.abstract
A NEW PUBLICATION FROM IEMEST'S RESEARCHERS EXPLAINS ONE OF THE MECHANISMS OF ACTION OF A CHEMOTHERAPICS
A group of IEMEST researchers, lead by Dr. Claudia Campanella, Head of the Section of studies on micro- and nano-vesicles as biomarkers, has showed for the first time one the mechnisms of action of a known chemotherapics, the SAHA (suberoylanilide hydroxamic acid). This mechanism involves the nitration of the mitochondrial protein HSP60. The latter, after nitration, is released from tumor cells by exosomes. HSP60 commonly protects tumor cells from stress. Its secretion through exosomes favours tumor cell death as well as activates an antitumor immune response. This paper has been published this month on ONCOTARGET (Impact factor: 6,359): http://www.impactjournals.com/oncotarget
On November 13th and 14th, during the conference “Science in Ancient / Science for Ancient. From scientific knowledge in the Hellenistic age to the virtual archeology” organized by the “Regione Siciliana”, the IEMEST researcher Francesco Di Paola will give a Lecture on “The Morgantina Silver Archaeological Treasure at the Museum of Aidone” with other colleagues in the field of Computer Science. The Morgantina Treasure is one of the most precious collections of the Archaeological Museum in Aidone, consisting of 16 pieces that were returned to Italy in 2010, following the 2006 agreement between the Italian and Sicilian governments and the Metropolitan Museum in New York. A police investigation determined that the provenance of the objects was the house of Eupolemos in Morgantina, where the precious items probably were hidden during the Second Punic War. Before the trip to New York the research team have been decided to examine the silver pieces through non-invasive diagnostic analysis and 3D survey to collect useful data both to monitor the conservation state over time (to check after four years) and to guarantee the virtual visit of the item during their absence.
The IEMEST's Researchers Filippo Macaluso, Kathy Myburgh and Giosuè Lo Bosco won the second call for innovative apps in the environmental and social domains, MYGEOSS project.
Our researchers proposed the "eQUOS" app (Environment Quality for Outdoor Sports): by using an open database tracking the changing environment, eQUOS will suggest to the final user whether to perform a specific outdoor physical activity in a specific geographical area on the basis of the environment quality, i.e. climate, water, coastal areas, and atmospheric composition. For further information, please visit: http://digitalearthlab.jrc.ec.europa.eu/mygeoss/results2.cfm
The Director of the Institute in the list of the Top Italian Scientists.
Prof. Francesco Cappello, Director of our Institute, has been included in the ranks of the Top Italian Scientists elaborated by VIA-Academy. This ranking includes Italian scientists of all disciplines (science and humanities) operating in Italy and in the world. The ranking is compiled based on h-index, the index that measures the number of international publications, and their impact on the international scientific community assessed on the number of citations received. For further information, please visit: http://www.topitalianscientists.org
A Potential Link between lipoproteins and asthma: a IEMEST's study
A recent study carried out by two research groups coordinated by Prof. Scichilone and Prof. Rizzo, IEMEST researchers, demonstrated for the first time that, in asthmatics, the least pro-inflammatory lipoproteins (LDL-1 e LDL-2) are reduced, and the pro-inflammatory (LDL-3 and LDL-4) elevated compared to healthy controls. In addition, in asthmatics the serum concentrations of LDL-1 are positively associated with lung function, whereas the pro-inflammatory LDL-3 are inversely correlated with lung function. These findings suggest that the LDL are implicated in the pathogenesis of asthma, in that, they may act by igniting the inflammatory cascade of the airways.
A new study correlates obesity associated with insulin resistance to Alzheimer's disease
Two researchers of our Institute are co-authors of a study carried out along with researchers of the C.N.R. of Palermo, which correlates the insulin resistance, that develops in some obese individuals, with the development of Alzheimer's disease. The study has been published on "Current Alzheimer Research". In particular, insulin resistance determines, among other damages, oxidative stress and mitochondrial dysfunction in neurons of the mice subjected to a high fat diet, and this leads to early damages that are pathognomonic for Alzheimer's disease. Treatment of metabolic disorders, then, can prevent the development of this serious neurodegenerative disease in this subpopulation of subjects. Part of this work was carried out by using the equipment of the Laboratory of Neuroanatomy funded by PON 'Research and Competitiveness' 2007-2013, measure 184.108.40.206.
Link to the paper: here
A novel biomarker for the colo-rectal cancer
A group of IEMEST’s researchers, coordinated by prof. Francesco Cappello, published a paper in the journal "CANCER" (the official journal of the American Cancer Society) on a new marker for the diagnosis and the follow-up of patients with colorectal carcinoma. In this work it has been shown that a stress protein (Hsp60) bound to exosomes (vesicles secreted by tumor cells) is present in very high levels in patients who undergo surgery while its levels are reduced drastically one week after the surgery. These results make exosomal Hsp60 a putative tool for the diagnosis and the follow-up of this cancer. The work was conducted in collaboration with researchers of the University of Palermo, the National Institute of Health in Rome and the University of Maryland at Baltimore, USA.
The paper can be read on-line: qui.
At the Euro-Mediterranean Institute of Science and Technology has been established an international research center devoted to the study of the chaperonopathies of the nervous system.
The Chaperoning System participates extensively in the development, functioning, protection, and repair of the nervous system from conception to old age. Read more here.
Giuseppe Venturella invited speaker at a congress on wild cherry.
Prof. Giuseppe Venturella, full professor of Forest Botany and Mycology and Leader of the "Environmental Botany and Mycology applied to agro-forest ecosystems" Section of IEMEST has been invited to give a talk titled "Botanical, ecological and distributive features of wild cherry" at the 46° Festival of Cherries that will be held on June 13th 2015 at Chiusa Sclafani (Palermo).
A young IEMEST’s researcher awarded for research on diabetes and hepatic diseases.
Dr. Angelo Maria Patti, member of the Section of Atherosclerosis, Diabetes and Cardiovascular Prevention headed by Prof. Manfred Rizzo, is among the four winners of the 1st scholarship in memory of Carmelo Schembari. Dr. Patti has been awarded for his research on metabolic effects of nutraceuticals in patients with diabetes mellitus type 2 and hepatic steatosis.
An authoritative "Position Paper" on physiological functions of extracellular vesicle.
Francesco Cappello, member of the Management Committee of the COST action-ME-HAD, is one of the authors of the important work on the physiological role of microvesicles and on exosomes. The focus on this topic is growing after the discovery that these vesicles can be taken from all human biological fluids (such as blood, urine, saliva, etc.) and can be used not only as diagnostic and prognostic markers but also as therapeutic tools of various human diseases, such as cancer, cardiovascular diseases and chronic inflammatory conditions. This study, published in the Journal of Extracellular Vesicles, can be read online here.
A hormone as a potential anticancer agent.
Two IEMEST’s researchers, Antonella Marino Gammazza and Francesco Cappello, have taken part to a study with colleagues of the Universities of Gdansk and Rzeszow, Poland, which has shown anti-tumor activity of 2-Methoxyestradiol, a physiological metabolite of estradiol, an estrogen hormone produced by the ovaries. This hormone showed to be able in arresting the cell cycle of cancer cells and inducing programmed cell death (apoptosis). This study has been published in the prestigious journal “Oncotarget”.The work can be read online here.
IEMEST’s researchers published a study of the alteration of glucose metabolism.
The research has been published in the Journal of Cell Physiology and highlighted the effects of the "glucagon-like peptide 2" (GLP-2) on the metabolism of mice treated with a high fat diet. GLP-2 acts as a protective factor against the alteration of glucose metabolism. The work can be read online here. Francesca Rappa and Francesco Cappello have taken part to this work.
A researcher at the Institute for Euro-Mediterranean Science and Technology in the Top Italian Scientist. Prof. Manfredi Rizzo, Director of the Department of Population Heath, Nutraceuticals and Biomarkers has entered the ranks of the Top Italian Scientist elaborated by VIA-Academy. This ranking includes Italian scientists of all disciplines (science and humanities) operating in Italy and in the world. The ranking is compiled based on h-index, the index that measures the number of international publications, and their impact on the international scientific community assessed on the number of citations received. http://www.topitalianscientists.org
Prof. Francesco Cappello will attend as Invited Speaker at the "Experimental Biology 2015" meeting (Boston, March 27st - April 1st) giving a talk titled "Role of chaperones in healthy bowel and IBD"
ACCORDO DI COLLABORAZIONE TRA IL DIPARTIMENTO DELLA PESCA MEDITERRANEA ASSESSORATO REGIONALE DELL'AGRICOLTURA, DELLO SVILUPPO RURALE E DELLA PESCA MEDITERRANEA E L'ISTITUTO EURO-MEDITERRANEO DI SCIENZA E TECNOLOGIA (IEMEST) PER LA REALIZZAZIONE DEL CLUSTER BIOMEDITERRANEO IN ATTUAZIONE DELLA CONVENZIONE TRA EXPO 2015 SpA E REGIONE SICILIANA - ASSESSORATO AGRICOLTURA, SVILUPPO RURALE E PESCA MEDITERRANEA
PROGETTO CYBER BRAIN: PRIMA PUBBLICAZIONE SU RIVISTA “NATURE”
The results of a study carried out by the Department of Medicine and Neuroscience of the Euro-Mediterranean Institute of Science and Technology (IEMEST) has been published on March 24th in an international journal, part of the Nature publishing group, called "Scientific Reports". Dr. Antonella Marino Gammazza, the principal investigator of the study, said: “The study is among the first to explore the relationship between temporal lobe epilepsy (TLE), the most frequent type of non-treatable epilepsy, and the expression of one of the most important anti-stress proteins, the Hsp60. The work was conducted using both an animal model and human samples. In the animal model, the level of Hsp60 was evaluated in the hippocampus and in blood. An increase of Hsp60 levels was observed not only in the hippocampus, but also in the plasma of the animals following epileptic seizures. The correlation between the increased expression of the protein in circulation and the high neuronal excitability is very interesting. Likewise, post-seizure Hsp60 levels in the plasma of patients were higher than before the seizure. In conclusion, high levels of Hsp60 could be considered a biomarker of stress, reflecting neuronal cell damage in the hippocampus”.
This study was conducted in collaboration with researchers from the IRCCS "NEUROMED" (Isernia, Italy), and is the first study conducted using the equipment acquired through the "CYBER BRAIN" PON 2007-2013 project, funded by the Ministry of Education (Project Code: PONa3_00210), for the establishment of an advanced neuroanatomy laboratory in Palermo at the IEMEST. Researchers from the University of Maryland, Baltimore, USA, from the University of Cardiff, UK, and from the University of Malta also took part in the work. The President of the IEMEST, Bartolomeo Sammartino, and the Director, Francesco Cappello, would like to express their satisfaction for the important goal achieved thanks to the PON funding received by the Institute and to the collaboration with other partners, including the IRCCS "Neuromed". The publication is available online:
Francesco Cappello, Director of the IEMEST, received the appointment as Adjunct Associate Professor at Temple University College of Science and Technology, Department of Biology, Philadelphia, USA. The recognition will lead to the development of new forms of collaboration between the two institutions in the field of biomedicine.
A researcher at the Institute for Euro-Mediterranean Science and Technology in the Top Italian Scientist.
Prof. Giovanni Li Volti, Director of the Department of Stress Biology, Epigenetics, Sport and Health has entered the ranks of the Top Italian Scientist elaborated by VIA-Academy. This ranking includes Italian scientists of all disciplines (science and humanities) operating in Italy and in the world. The ranking is compiled based on h-index, the index that measures the number of international publications, and their impact on the international scientific community assessed on the number of citations received. Among the names that stand out in the top of the rankings we found researchers such as: Carlo Croce, Giuseppe Remuzzi, Umberto Veronesi, Silvio Garattini, Carlo Rubbia and Antonio Zichichi. "I feel very honored to be part of such a prestigious ranking," said Prof. Li Volti "I feel proud to represent my country and particularly young researchers of the south of our country." "Obviously," says Li Volti, "we must take into account the limitations of the standings. The h-factor functions primarily as a comparison among researchers of the same subject area, and favors those who have a long career behind compared to the young, as brilliant. The index varies in fact considerably between different fields (for example, is quite high in the biomedical field and in physics). Furthermore, use of these bibliometric data usually disadvantages researchers not publishing in English"
SCOPERTA DEL SITO MEGALITICO DELLA “PETRA DELLA MADONNA” A VALLEDOLMO - Relationship of Prof. Carmelo Montagna
Partecipants: Angileri Francesca, Francesco Cappello and Alberto JL Macario, IEMEST researchers
Going International releases a page to the IEMEST website on Chaperonopathies, diseases related to the anti-stress mechanisms. Going international is the largest European provider and the most important platform of information in the field of medical science and health.
Life Safety and Security (LiSS), the IEMEST's new open access Scientific Journal, has been introduced by Going International in the section "Special of the month". Read the article at: http://www.goinginternational.eu/wp/de/?p=2715
the Vacancies for the Biologist and Biotechnologist published on September 19th 2013 were withdrawn for technical reasons.
In the future we will publish new Vacancies.
Masters of Studies for the Year 2013-2014
in partnership with The University LUde.S. - Free University of Human Sciences and Technology of Lugano, Switzerland:
The deadline for applications has been extended to October 31st, 2013, for all Master Courses.
The call for the Project Training with Scholarship entitled "Higher Education for Innovation Pole Cyber Brain" has been published. Application deadline: 31 July 2013.
An important study about aging and liver diseases
The process of aging predisposes to hepatic functional impairment. Therefore, understanding how aging could affect the molecular pathology of liver diseases is important. In the review “Liver disease and aging: friends or foes?” appeared on the prestigious journal Aging Cell, our IEMEST researcher Dr. Manlio Vinciguerra, also Senior Lecturer at the University College London, discusses why common liver diseases such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma surprisingly occur less frequently in the very elderly (individuals aged more than 70).
Ref: Sheedfar F, Di Biase S, Koonen D, Vinciguerra M. Liver diseases and aging: friends or foes? Aging Cell. 2013 Jul 1. doi: 10.1111/acel.12128. [Epub ahead of print]
BANDO DI CONCORSO PER TITOLI PER IL CONFERIMENTO
DI UN PREMIO DI RICERCA PER GIOVANI RICERCATORI
Bando per la selezione di idee e progetti innovativi
CALL FOR PROPOSALS
“WORKING INTELLIGENCE, SPREADING KNOWLEDGE”
Lo IEMEST organizza il corso di I livello di GIS che offre ai suoi iscritti la possibilità di migliorare le competenze di giovani laureati, professionisti e impiegati della pubblica amministrazione circa l'uso delle nuove tecnologie applicate alla gestione dell'informazione geografica digitale in ambiente GIS (Geographical Information System) per la pianificazione del territorio e dell'ambiente.
IEMEST: A new vision and platform to enhance the progress of research and dissemination of knowledge in natural and social sciences
Published by: Going International Information Services
CHRONIC OBSTRUCTIVE PULMONARY DISEASE:
NEW EVIDENCES ON ITS PATHOGENESIS
Published in PLOS ONE
Chronic obstructive pulmonary disease (COPD) is one of the most severe conditions caused primarily by cigarette smoke and characterized by a progressive airway obstruction. Many people each year die from complications of this disease worldwide. In a study conducted by researchers from many institutions - among which the IEMEST, the "S. Maugeri " Foundation, and the Universities of Palermo, Ferrara, Torino and Padova, new molecules involved in induction and maintenance of the inflammation that underlies the obstruction of the airways have been identified. <<These molecules are called "chaperones" or "heat shock proteins">> says prof. Cappello, principal investigator in this study, <<and while they are physiologically devoted to protect cells from stress induced by various factors (e.g., cigarette smoking) in this disease some of them are overexpressed and they may increase the activity of inflammatory cells . In this paper we describe for the first time some molecular mechanisms involved in its overexpression. These results may lead to more effective therapies for COPD>>.
This publication can be downloaded through this link: http://dx.plos.org/10.1371/journal.pone.0028200
Cordonal stem cells as new promising therapeutic tools
Cells from the Umbilical cord’s Wharton jelly (WJC) are promising tools for the treatment of cancer, muscolo-skeletal, neurodegenerative, hepato-pancreatic diseases. Following the recent advances in the field, the international scientific journal “The Open Tissue Engineering and Regenerative Medicine Journal” just published a special issue titled “Wharton’s jelly mesenchymal stem cells: tissue regeneration and beyond”, guest edited by Dr Giampiero La Rocca, IEMEST researcher. Contributions were from many pioneers in the field of WJC: International authors were from top laboratories in Belgium, Canada, Germany, India, Japan, Switzerland and USA. Italian groups were from the Universities of Chieti, Milano, Padova and Palermo. Different aspects of WJC biology, immune features, disease indications, were discussed in a series of authoritative reviews. Selected original papers provide novel findings on isolation, culturing, features and uses of WJC for cellular therapy. Taken together, the issue provides key advances on the definition of the new frontiers which can be reached, further moving on the current targets of WJC-based regenerative medicine.
The special issue is available for free download at this address: http://www.benthamscience.com/open/totermj/openaccess2.htm
New discovery: two new molecules predictive for acute myocardial infarct
In this pilot study published in Translational Research (2011;157:285–292), we determined serum levels of Hsp60 and Hsp32 in 40 patients with acute myocardial infarction (AMI) to assess their clinical significance and potential prognostic value. We also performed a bioinformatics analysis of the two molecules in search of structural clues on the mechanism of their release from cells. All patients were followed up for 6 months to register adverse post-AMI cardiovascular events
A multivariate analysis demonstrated that elevated Hsp60 was predictive of post-AMI adverse events. In contrast, increased Hsp32 levels showed a significant association with less severity of coronary artery diseases. Moreover, our findings suggest that Hsp60 and Hsp32 play distinct roles in the pathogenesis of AMI.
L’Istituto Euro Mediterraneo di Scienza e Tecnologia (IEMEST), il Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BIONEC) dell’Università degli Studi di Palermo e l’Ente Regionale per il Diritto allo Studio Universitario (ERSU) di Palermo;
il bando di concorso:
Concorso di arti visive e applicate in onore delle celebrazioni del 500° anniversario dalla nascita di Giovanni Filippo Ingrassia
Bando di Concorso per titoli per il conferimento di una Borsa di Studio per attività di ricerca su un progetto dal titolo:
"Studio bioinformatico e computazionale della chaperonina mitocondriale umana Hsp10"
A new discovery on inflammatory bowel diseases published on “Cell Stress and Chaperones”
The purpose of this work was to determine in colon mucosa of Crohn’s disease (CD) and ulcerative colitis (UC) in relapse: a) the levels of the chaperonins Hsp60 and Hsp10; b) the quantity of inflammatory cells. Both Hsp60 and Hsp10, as well as inflammatory cells, occurred in the mucosa of CD and UC but not in NC. Hsp60 and Hsp10 co-localised to epithelial cells of mucosal glands but not always in connective tissue cells of lamina propria, where only Hsp60 or, less often, Hsp10 was found. Since chaperonins are key factors in the activation of the immune system leading to inflammation, we propose that they play a central role in the pathogenesis of the two diseases, which, consequently, ought to be studied as chaperonopathies.
A protein secreted by tumor cells may become a new diagnostic and therapeutic target
published in PLoS ONE
Levels of Hsp60 in tumors are often at high levels. Moreover, Hsp60 may be found in sera of patients with tumor. Data presented in this work suggest that Hsp60 release from tumor cells is the result of an active secretion mechanism and, since extracellular release of the chaperone was demonstrated in all tumor cell lines investigated, our observations most likely reflect a general physiological phenomenon, occurring in many tumors. Finally, we showed that Hsp60 is present in tumor cell membrane. These results may have diagnostic and prognostic, as well as therapeutic significance.
New discovery: A new scaffold to differentiate cardiac precursors in myocardiocytes
Published in Journal of Cellular Physiology
In the last few years, a major goal of cardiac research has been to drive stem cell differentiation to replace damaged myocardium and several research groups have attempted to differentiate potential cardiac stem cells (CSCs). In the present study, we isolated a pool of small proliferating and fibroblast-like cells from adult rat myocardium. The phenotype of these cells was assessed and the characterized cells were cultured in a collagen I/OPLA scaffold with horse serum to obtain fine myocardial differentiation. The results open new biomedical and therapeutical scenarios.
New discovery: Chlamydia Trachomatis infection consequences: autoimmune diseases or anticancer immunity?
published in PLoS Pathogens
Chlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. This article focuses on the potential pathogenetic effect of Hsp60 production from Chlamydia trachomatis that shares various antigenic determinants with the human counterpart. At the same time, we remark that pre-tumor and tumor cells expressing Hsp60 on their surface can be destroyed with participation of the anti-Hsp60 antibody, thus stopping cancer progression before it is even noticed by the patient or physician.